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Comment
. 2018 May 10;9(5):557.
doi: 10.1038/s41419-018-0630-x.

Fructose fuels lung adenocarcinoma through GLUT5

Yuanyuan Weng  1 , Jin Zhu  1 , Zhenhong Chen  2 , Jingqi Fu  3 , Feng Zhang  4
Affiliations
Comment

Fructose fuels lung adenocarcinoma through GLUT5

Yuanyuan Weng et al. Cell Death Dis. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Fructose promotes lung adenocarcinoma cell survival and metastasis through GLUT5.
LUAD cells utilize both glucose and fructose as nutrients for energetic and biosynthetic purposes. Especially, when glucose is scarce, fructose may function as a crucial alternative. Fructose, ingested through GLUT5, could efficiently enhance cancer cell proliferation, migration, invasion, and tumorigenicity. Compared to glucose, fructose metabolism facilitates intracellular FFA accumulation and ATP production while decreases NADPH and lactate in LUAD cells. The green arrow indicates that fructose produces less metabolites than glucose under the same concentration, while the red arrow indicates the opposite trend. FFA free fatty acid, 2,5-Anhydro-D-mannitol fructose analog with high affinity for GLUT5
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