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Comment
. 2018 Jul;84(7):1624-1625.
doi: 10.1111/bcp.13606. Epub 2018 May 10.

Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker

Caroline Gjestad  1 , Tore Haslemo  1 , Ole A Andreassen  2   3 , Espen Molden  1   4
Affiliations
Comment

Gjestad et al. reply to 'Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?' by Neuhoff and Tucker

Caroline Gjestad et al. Br J Clin Pharmacol. 2018 Jul.
No abstract available

Keywords: 4β-hydroxycholesterol; CYP3A4; quetiapine.

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References

    1. Gjestad C, Haslemo T, Andreassen OA, Molden E. 4β‐Hydroxycholesterol level significantly correlates with steady‐state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. Br J Clin Pharmacol 2017; 83: 2398–2405. - PMC - PubMed
    1. Neuhoff S, Tucker GT. Was 4β‐hydroxycholesterol ever going to be a useful marker of CYP3A4 activity? Br J Clin Pharmacol 2018; 84: 1620–1621. - PMC - PubMed
    1. Vanhove T, Hasan M, Annaert P, Oswald S, Kuypers DRJ. Pretransplant 4β‐hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. Br J Clin Pharmacol 2017; 83: 2406–2415. - PMC - PubMed
    1. de Jonge H, Vanhove T, de Loor H, Verbeke K, Kuypers DRJ. Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit. Br J Clin Pharmacol 2015; 80: 548–559. - PMC - PubMed
    1. Hole K, Storset E, Olastuen A, Haslemo T, Kro GB, Midtvedt K, et al Recovery of CYP3A phenotype after kidney transplantation. Drug Metab Dispos 2017; 45: 1260–1265. - PubMed

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