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Review
. 2018 Jul:71:1-17.
doi: 10.1016/j.plipres.2018.05.002. Epub 2018 May 8.

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Marc P Baggelaar  1 , Mauro Maccarrone  2 , Mario van der Stelt  3
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Free article
Review

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Marc P Baggelaar et al. Prog Lipid Res. 2018 Jul.
Free article

Abstract

2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.

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