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Review
. 2018 May 3;9(5):235.
doi: 10.3390/genes9050235.

The Most Important Virulence Markers of Yersinia enterocolitica and Their Role during Infection

Agata Bancerz-Kisiel  1 , Marta Pieczywek  2 , Piotr Łada  3 , Wojciech Szweda  4
Affiliations
Review

The Most Important Virulence Markers of Yersinia enterocolitica and Their Role during Infection

Agata Bancerz-Kisiel et al. Genes (Basel). .

Abstract

Yersinia enterocolitica is the causative agent of yersiniosis, a zoonotic disease of growing epidemiological importance with significant consequences for public health. This pathogenic species has been intensively studied for many years. Six biotypes (1A, 1B, 2, 3, 4, 5) and more than 70 serotypes of Y. enterocolitica have been identified to date. The biotypes of Y. enterocolitica are divided according to their pathogenic properties: the non-pathogenic biotype 1A, weakly pathogenic biotypes 2⁻5, and the highly pathogenic biotype 1B. Due to the complex pathogenesis of yersiniosis, further research is needed to expand our knowledge of the molecular mechanisms involved in the infection process and the clinical course of the disease. Many factors, both plasmid and chromosomal, significantly influence these processes. The aim of this study was to present the most important virulence markers of Y. enterocolitica and their role during infection.

Keywords: Yersinia adhesin YadA; Yersinia enterocolitica; Yersinia outer membrane proteins Yops; Yersinia-stable toxin Yst; attachment-invasion locus protein Ail; invasin InvA; mucoid Yersinia factor MyfA; pYV; virulence markers.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The role of selected regulatory genes in Yersinia enterocolitica virulence markers expression.
See this image and copyright information in PMC

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