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Review
. 2018 May 3;9(5):237.
doi: 10.3390/genes9050237.

Genetic Mechanisms of Asthma and the Implications for Drug Repositioning

Yue Huo  1 , Hong-Yu Zhang  2
Affiliations
Review

Genetic Mechanisms of Asthma and the Implications for Drug Repositioning

Yue Huo et al. Genes (Basel). .

Abstract

Asthma is a chronic disease that is caused by airway inflammation. The main features of asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The disease is mainly managed using drug therapy. The current asthma drug treatments are divided into two categories, namely, anti-inflammatory drugs and bronchodilators. However, disease control in asthma patients is not very efficient because the pathogenesis of asthma is complicated, inducing factors that are varied, such as the differences between individual patients. In this paper, we delineate the genetic mechanisms of asthma, and present asthma-susceptible genes and genetic pharmacology in an attempt to find a diagnosis, early prevention, and treatment methods for asthma. Finally, we reposition some clinical drugs for asthma therapy, based on asthma genetics.

Keywords: asthma; disease-susceptible genes; drug repositioning.

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Conflict of interest statement

The authors declare no conflict of interest.

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