Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May 11;5(2):29.
doi: 10.3390/jcdd5020029.

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

Sofya Pozdniakova  1   2 , Yury Ladilov  3   4
Affiliations
Review

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

Sofya Pozdniakova et al. J Cardiovasc Dev Dis. .

Abstract

Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3'⁻5'-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity, selectivity and signal strength. One important player in cAMP signaling is soluble adenylyl cyclase (sAC). The intracellular localization of sAC allows for the formation of unique intracellular cAMP microdomains that control various physiological and pathological processes. This review is focused on the functional role of sAC-produced cAMP. In particular, we examine the role of sAC-cAMP in different cellular compartments, such as cytosol, nucleus and mitochondria.

Keywords: adcy10; cAMP; compartmentalization; phosphodiesterase.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Intracellular distribution of sAC-dependent cAMP pool. sAC, soluble adenylyl cyclase; PKA, protein kinase A, EPAC, exchange protein directly activated by cAMP; CNGC, cyclic nucleotide gated channels; PDE, phosphodiesterase.
See this image and copyright information in PMC

References

    1. Wu Z., Huang X., Feng Y., Handschin C., Feng Y., Gullicksen P.S., Bare O., Labow M., Spiegelman B., Stevenson S.C. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells. Proc. Natl. Acad. Sci. USA. 2006;103:14379–14384. doi: 10.1073/pnas.0606714103. - DOI - PMC - PubMed
    1. Chowanadisai W., Bauerly K.A., Tchaparian E., Wong A., Cortopassi G.A., Rucker R.B. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1α expression. J. Biol. Chem. 2010;285:142–152. doi: 10.1074/jbc.M109.030130. - DOI - PMC - PubMed
    1. Catterall W.A. Regulation of cardiac calcium channels in the fight-or-flight response. Curr. Mol. Pharmacol. 2015;8:12–21. doi: 10.2174/1874467208666150507103417. - DOI - PMC - PubMed
    1. Kashina A.S., Semenova I.V., Ivanov P.A., Potekhina E.S., Zaliapin I., Rodionov V.I. Protein kinase A, which regulates intracellular transport, forms complexes with molecular motors on organelles. Curr. Biol. 2004;14:1877–1881. doi: 10.1016/j.cub.2004.10.003. - DOI - PubMed
    1. Burdyga A., Conant A., Haynes L., Zhang J., Jalink K., Sutton R., Neoptolemos J., Costello E., Tepikin A. cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC. Biochim. Biophys. Acta. 2013;1833:2664–2672. doi: 10.1016/j.bbamcr.2013.06.011. - DOI - PMC - PubMed

LinkOut - more resources