Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2018 Aug;24(8):1692-1698.
doi: 10.1016/j.bbmt.2018.05.004. Epub 2018 May 9.

Engagement with INSPIRE, an Online Program for Hematopoietic Cell Transplantation Survivors

Karen L Syrjala  1 , Marie-Laure Crouch  2 , Wendy M Leisenring  2 , Mary E D Flowers  3 , Samantha B Artherholt  3 , Allison Stover Fiscalini  2 , Eleni Romano  2 , Joan M Romano  4 , Paul J Martin  3 , Jean C Yi  2
Affiliations
Randomized Controlled Trial

Engagement with INSPIRE, an Online Program for Hematopoietic Cell Transplantation Survivors

Karen L Syrjala et al. Biol Blood Marrow Transplant. 2018 Aug.

Abstract

In a secondary analysis of a randomized controlled trial (RCT), we examined participants' engagement with INSPIRE, a personalized online program for hematopoietic cell transplantation (HCT) survivors that focuses on cancer-related distress, depression, fatigue, and health care needs. We approached all adult, 3- to 18-year HCT survivors treated for hematologic malignancy without relapse or second cancer in the previous 2 years for participation in an RCT with either immediate or delayed access to INSPIRE. Participants with immediate access could view the online material at any time. Data included page view tracking, medical records, and patient-reported outcomes, including the Short Form 36 and Cancer and Treatment Distress (CTXD) measures. Of 1322 eligible HCT survivors, 771 (58%) completed the baseline assessment, and 451 received immediate INSPIRE access and were included in analyses. The cohort was 56% male, with a mean age of 52 ± 12.2 years, and 26% received an autologous transplant. Most (77%) logged into the INSPIRE site at least once, and 48% viewed ≥8 pages. Survivors who viewed ≥2 pages were more likely to be age ≥40 years (relative risk [RR], 1.41; 95% confidence interval [CI], 1.10 to 1.80), to be female (RR, 1.22; 95% CI, 1.07 to 1.40), to have chronic graft-versus-host disease (RR, 1.28; 95% CI, 1.08 to 1.51), to be less than 10 years post-HCT (RR, 1.19; 95% CI, 1.01 to 1.39), and to have moderate CTXD distress (RR, 1.34; 95% CI, 1.14 to 1.57). Engagement did not differ by race, education, income, rural/urban residence, computer experience, donor type, or depression (all P ≥ .50). The INSPIRE online program was widely used, including by those who often have reduced access to care after treatment.

Keywords: Blood and marrow transplantation; Cancer survivors; Engagement; Hematologic malignancy; Hematopoietic cell transplantation; Internet; Online; Website.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: There are no conflicts of interest to report.

Figures

Figure 1.
Figure 1.
Study flow diagram.
Figure 2.
Figure 2.
Number of days from being given INSPIRE access to first page visit (n = 451).
Figure 3.
Figure 3.
Distribution of page views of content sections for participants with immediate access to the INSPIRE site pages (8065 total page views).
See this image and copyright information in PMC

References

    1. Kontos E, Blake KD, Chou WY, Prestin A. Predictors of eHealth usage: insights on the digital divide from the Health Information National Trends Survey 2012. J Med Internet Res 2014;16(7):e172. - PMC - PubMed
    1. Martin PJ, Counts GW Jr, Appelbaum FR, et al. Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation. J Clin Oncol 2010;28(6):1011–1016. - PMC - PubMed
    1. Syrjala KL, Martin PJ, Lee SJ. Delivering care to long-term adult survivors of hematopoietic cell transplantation. J Clin Oncol 2012;30(30):3746–3751. - PMC - PubMed
    1. Baker KS, Armenian S, Bhatia S. Long-term consequences of hematopoietic stem cell transplantation: current state of the science. Biol Blood Marrow Transplant 2010;16(1 Suppl):S90–S96. - PMC - PubMed
    1. Khera N, Storer B, Flowers ME, et al. Nonmalignant late effects and compromised functional status in survivors of hematopoietic cell transplantation. J Clin Oncol 2012;30(1):71–77. - PMC - PubMed

Publication types

LinkOut - more resources