Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan;45(1):82-85.
doi: 10.1007/s00134-018-5213-x. Epub 2018 May 12.

The ten pitfalls of lactate clearance in sepsis

Glenn Hernandez  1 , Rinaldo Bellomo  2   3   4   5 , Jan Bakker  6   7   8   9
Affiliations

The ten pitfalls of lactate clearance in sepsis

Glenn Hernandez et al. Intensive Care Med. 2019 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Fig. 1
Fig. 1
Flowchart on the clinical use of increased lactate levels. ScvO2 central venous hemoglobin oxygenation, dPCO2 central venous–arterial PCO2 difference
See this image and copyright information in PMC

Comment in

  • The 11th pitfall: thiamine deficiency.
    Ricci Z, Romagnoli S. Ricci Z, et al. Intensive Care Med. 2018 Sep;44(9):1597. doi: 10.1007/s00134-018-5271-0. Epub 2018 Jun 22. Intensive Care Med. 2018. PMID: 29934922 No abstract available.

References

    1. Vincent JL, Quintairos ESA, Couto L, Jr, Taccone FS. The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care. 2016;20:257. doi: 10.1186/s13054-016-1403-5. - DOI - PMC - PubMed
    1. Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, Grimaud D. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med. 1998;157:1021–1026. doi: 10.1164/ajrccm.157.4.9705037. - DOI - PubMed
    1. Tapia P, Soto D, Bruhn A, Alegria L, Jarufe N, Luengo C, Kattan E, Regueira T, Meissner A, Menchaca R, Vives MI, Echeverria N, Ospina-Tascon G, Bakker J, Hernandez G. Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care. 2015;19:188. doi: 10.1186/s13054-015-0928-3. - DOI - PMC - PubMed
    1. Garcia-Alvarez M, Marik P, Bellomo R. Sepsis-associated hyperlactatemia. Crit Care. 2014;18:503. doi: 10.1186/s13054-014-0503-3. - DOI - PMC - PubMed
    1. Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, Duncan CA, Harman EM, Henderson GN, Jenkinson S. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. N Engl J Med. 1992;327:1564–1569. doi: 10.1056/NEJM199211263272204. - DOI - PubMed