The ten pitfalls of lactate clearance in sepsis

doi:10.1007/s00134-018-5213-x

. 2019 Jan;45(1):82-85.

doi: 10.1007/s00134-018-5213-x. Epub 2018 May 12.

The ten pitfalls of lactate clearance in sepsis

Glenn Hernandez¹, Rinaldo Bellomo^{2

3

4

5}, Jan Bakker^{6

7

8

9}

Affiliations

¹ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
² Department of Intensive Care, Austin Hospital, Melbourne, Australia.
³ Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia.
⁴ Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, Australia.
⁵ School of Medicine, The University of Melbourne, Melbourne, Australia.
⁶ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. jan.bakker@erasmusmc.nl.
⁷ Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, Netherlands. jan.bakker@erasmusmc.nl.
⁸ Department of Pulmonology and Critical Care, Columbia University Medical Center, New York, USA. jan.bakker@erasmusmc.nl.
⁹ Department of Pulmonology and Critical Care, New York University Medical Center - Langone, New York, USA. jan.bakker@erasmusmc.nl.

PMID: 29754310
PMCID: PMC6334727
DOI: 10.1007/s00134-018-5213-x

The ten pitfalls of lactate clearance in sepsis

Glenn Hernandez et al. Intensive Care Med. 2019 Jan.

. 2019 Jan;45(1):82-85.

doi: 10.1007/s00134-018-5213-x. Epub 2018 May 12.

Authors

Glenn Hernandez¹, Rinaldo Bellomo^{2

3

4

5}, Jan Bakker^{6

7

8

9}

Affiliations

¹ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
² Department of Intensive Care, Austin Hospital, Melbourne, Australia.
³ Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia.
⁴ Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, Australia.
⁵ School of Medicine, The University of Melbourne, Melbourne, Australia.
⁶ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. jan.bakker@erasmusmc.nl.
⁷ Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, Netherlands. jan.bakker@erasmusmc.nl.
⁸ Department of Pulmonology and Critical Care, Columbia University Medical Center, New York, USA. jan.bakker@erasmusmc.nl.
⁹ Department of Pulmonology and Critical Care, New York University Medical Center - Langone, New York, USA. jan.bakker@erasmusmc.nl.

PMID: 29754310
PMCID: PMC6334727
DOI: 10.1007/s00134-018-5213-x

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

**Fig. 1**
Flowchart on the clinical use of increased lactate levels. *ScvO2* central venous hemoglobin oxygenation, *dPCO2* central venous–arterial PCO₂ difference

See this image and copyright information in PMC

Comment in

The 11th pitfall: thiamine deficiency.
Ricci Z, Romagnoli S. Ricci Z, et al. Intensive Care Med. 2018 Sep;44(9):1597. doi: 10.1007/s00134-018-5271-0. Epub 2018 Jun 22. Intensive Care Med. 2018. PMID: 29934922 No abstract available.

Cited by

Does lactate enhance the prognostic accuracy of the quick Sequential Organ Failure Assessment for adult patients with sepsis? A systematic review.
Gill A, Ackermann K, Hughes C, Lam V, Li L. Gill A, et al. BMJ Open. 2022 Oct 21;12(10):e060455. doi: 10.1136/bmjopen-2021-060455. BMJ Open. 2022. PMID: 36270756 Free PMC article.
Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflammation and Oxidative Stress and Their Relationship with Organ Dysfunction in Human Septic Shock.
Reina-Couto M, Santos-Oliveira M, Pereira-Terra P, Silva-Pereira C, Quelhas-Santos J, Duarte Á, Martins S, Serrão P, Dias CC, Morato M, Guimarães JT, Roncon-Albuquerque R, Paiva JA, Albino-Teixeira A, Sousa T. Reina-Couto M, et al. Biomedicines. 2022 Nov 8;10(11):2845. doi: 10.3390/biomedicines10112845. Biomedicines. 2022. PMID: 36359365 Free PMC article.
Relation Between Multiplication of Venous Carbon Dioxide Partial Pressure (PvCO2) and the Ratio of Gas Flow to Pump Flow (Ve/Q) with Hyperlactatemia During Cardiopulmonary Bypass.
Kowara Y, Setiawan P, Airlangga PS, Abbas KA, Perdhana F, Husain TA, Semedi BP. Kowara Y, et al. Ann Card Anaesth. 2024 Oct 1;27(4):337-343. doi: 10.4103/aca.aca_94_24. Epub 2024 Oct 4. Ann Card Anaesth. 2024. PMID: 39365132 Free PMC article.
Effects of Fluids on the Sublingual Microcirculation in Sepsis.
Cusack R, O'Neill S, Martin-Loeches I. Cusack R, et al. J Clin Med. 2022 Dec 8;11(24):7277. doi: 10.3390/jcm11247277. J Clin Med. 2022. PMID: 36555895 Free PMC article. Review.
Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial.
Noormandi A, Khalili H, Mohammadi M, Abdollahi A. Noormandi A, et al. Eur J Clin Pharmacol. 2020 Feb;76(2):175-184. doi: 10.1007/s00228-019-02788-w. Epub 2019 Dec 9. Eur J Clin Pharmacol. 2020. PMID: 31814044 Clinical Trial.

See all "Cited by" articles

References

1. Vincent JL, Quintairos ESA, Couto L, Jr, Taccone FS. The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care. 2016;20:257. doi: 10.1186/s13054-016-1403-5. - DOI - PMC - PubMed
1. Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, Grimaud D. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med. 1998;157:1021–1026. doi: 10.1164/ajrccm.157.4.9705037. - DOI - PubMed
1. Tapia P, Soto D, Bruhn A, Alegria L, Jarufe N, Luengo C, Kattan E, Regueira T, Meissner A, Menchaca R, Vives MI, Echeverria N, Ospina-Tascon G, Bakker J, Hernandez G. Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care. 2015;19:188. doi: 10.1186/s13054-015-0928-3. - DOI - PMC - PubMed
1. Garcia-Alvarez M, Marik P, Bellomo R. Sepsis-associated hyperlactatemia. Crit Care. 2014;18:503. doi: 10.1186/s13054-014-0503-3. - DOI - PMC - PubMed
1. Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, Duncan CA, Harman EM, Henderson GN, Jenkinson S. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. N Engl J Med. 1992;327:1564–1569. doi: 10.1056/NEJM199211263272204. - DOI - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information

[1] Vincent JL, Quintairos ESA, Couto L, Jr, Taccone FS. The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care. 2016;20:257. doi: 10.1186/s13054-016-1403-5. - DOI - PMC - PubMed

[2] Vincent JL, Quintairos ESA, Couto L, Jr, Taccone FS. The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care. 2016;20:257. doi: 10.1186/s13054-016-1403-5. - DOI - PMC - PubMed

[3] Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, Grimaud D. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med. 1998;157:1021–1026. doi: 10.1164/ajrccm.157.4.9705037. - DOI - PubMed

[4] Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, Grimaud D. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med. 1998;157:1021–1026. doi: 10.1164/ajrccm.157.4.9705037. - DOI - PubMed

[5] Tapia P, Soto D, Bruhn A, Alegria L, Jarufe N, Luengo C, Kattan E, Regueira T, Meissner A, Menchaca R, Vives MI, Echeverria N, Ospina-Tascon G, Bakker J, Hernandez G. Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care. 2015;19:188. doi: 10.1186/s13054-015-0928-3. - DOI - PMC - PubMed

[6] Tapia P, Soto D, Bruhn A, Alegria L, Jarufe N, Luengo C, Kattan E, Regueira T, Meissner A, Menchaca R, Vives MI, Echeverria N, Ospina-Tascon G, Bakker J, Hernandez G. Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care. 2015;19:188. doi: 10.1186/s13054-015-0928-3. - DOI - PMC - PubMed

[7] Garcia-Alvarez M, Marik P, Bellomo R. Sepsis-associated hyperlactatemia. Crit Care. 2014;18:503. doi: 10.1186/s13054-014-0503-3. - DOI - PMC - PubMed

[8] Garcia-Alvarez M, Marik P, Bellomo R. Sepsis-associated hyperlactatemia. Crit Care. 2014;18:503. doi: 10.1186/s13054-014-0503-3. - DOI - PMC - PubMed

[9] Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, Duncan CA, Harman EM, Henderson GN, Jenkinson S. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. N Engl J Med. 1992;327:1564–1569. doi: 10.1056/NEJM199211263272204. - DOI - PubMed

[10] Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, Duncan CA, Harman EM, Henderson GN, Jenkinson S. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. N Engl J Med. 1992;327:1564–1569. doi: 10.1056/NEJM199211263272204. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The ten pitfalls of lactate clearance in sepsis

Affiliations

The ten pitfalls of lactate clearance in sepsis

Authors

Affiliations

Conflict of interest statement

Figures

Comment in

Similar articles

Cited by

References

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Conflict of interest statement

Figures

Comment in

Similar articles

Cited by

References

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical