Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Nov;58(5):665-7.
doi: 10.1038/bjc.1988.282.

Therapeutic ratio of photodynamic therapy in the treatment of superficial tumours of skin and subcutaneous tissues in man

D Gilson  1 , D Ash, I Driver, J W Feather, S Brown
Affiliations
Free PMC article

Therapeutic ratio of photodynamic therapy in the treatment of superficial tumours of skin and subcutaneous tissues in man

D Gilson et al. Br J Cancer. 1988 Nov.
Free PMC article

Abstract

Six patients with a total of 34 assessible subcutaneous or cutaneous lesions were treated with photodynamic therapy using 1.0, 1.5 or 2.0 mg kg-1 of photofrin II and 25-100 J cm-2 of red light (630 nm). The incidence of complete tumour response and skin necrosis were used to try to assess the therapeutic ratio of photodynamic therapy. The tumour response rate was 47%. The rate of tumour control and necrosis increased in parallel with dose of photosensitizer and light used, implying a low therapeutic ratio. However, the use of necrosis with eschar formation as an end-point for severe normal tissue damage is questioned as the skin healed completely in all cases and with minimal discomfort to the patients.

PubMed Disclaimer

References

    1. Cancer Res. 1978 Aug;38(8):2628-35 - PubMed
    1. Cancer Res. 1979 Jan;39(1):146-51 - PubMed
    1. J Natl Cancer Inst. 1979 Feb;62(2):231-7 - PubMed
    1. J Natl Cancer Inst. 1961 Jan;26:1-11 - PubMed
    1. Eur J Surg Oncol. 1985 Mar;11(1):47-50 - PubMed

Publication types