Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Mar 20:2018:3168452.
doi: 10.1155/2018/3168452. eCollection 2018.

SAPHO Syndrome Masquerading as Metastatic Breast Cancer

Devin Malik  1 , Richa Handa  2 , Andrew Petraszko  3 , Sheela Tejwani  1
Affiliations
Case Reports

SAPHO Syndrome Masquerading as Metastatic Breast Cancer

Devin Malik et al. Case Rep Rheumatol. .

Abstract

SAPHO syndrome is a rare clinical entity composed of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO). We describe a case of SAPHO syndrome masquerading as metastatic breast cancer in a patient with localized breast cancer who presented with cord compression. There was no pathologic evidence of metastatic cancer; however, a bone scan indicated osseous involvement. After multidisciplinary review of images and with additional findings of pustulosis and acne, a clinical diagnosis of SAPHO was made.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Anterior and posterior planar images of a 99mTc MDP bone scan show increased radiotracer uptake within the medial left clavicle and manubrium centered upon the left sternoclavicular joint and bilateral 1st costomanubrial joints. There is also increased radiotracer uptake with the cervical spine.
Figure 2
Figure 2
Photograph of the left palm demonstrating healed pustules. Similar findings were on the right palm.
Figure 3
Figure 3
Photograph of the left sole lesions demonstrating pustulosis. Similar findings were on the right sole.
See this image and copyright information in PMC

References

    1. Windom R. E., Sandford J. P., Ziff M. Acne conglobata and arthritis. Arthritis & Rheumatism. 1961;4(6):632–635. doi: 10.1002/art.1780040609. - DOI - PubMed
    1. Chamot A., Benhamou C. L., Kahn M. F., et al. Le syndrome acne pustulose hyperostose osteite (SA-PHO) Revue du Rhumatisme. 1987;54:187–196. - PubMed
    1. Hyodoh K., Sugimoto H. Pustulotic arthro-osteitis: defining the radiologic spectrum of the disease. Seminars in Musculoskeletal Radiology. 2001;5(2):89–93. doi: 10.1055/s-2001-15658. - DOI - PubMed
    1. Jansson A. F., Grote V., ESPED Study Group Nonbacterial osteitis in children: data of a German Incidence Surveillance Study. Acta Paediatrica. 2011;100(8):1150–1157. doi: 10.1111/j.1651-2227.2011.02205.x. - DOI - PubMed
    1. Hayem G. SAPHO syndrome. La Revue Du Praticien. 2004;54:1635–1636. - PubMed

Publication types

LinkOut - more resources