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. 2018 Jun 1;116(3):e451-e454.
doi: 10.5546/aap.2018.e451.

[Use of posaconazole in children: Experience in a tertiary pediatric hospital]

[Article in Spanish]
María T Rosanova  1 , Carla Voto  2 , María S Mussini  2 , Claudia Sarkis  2 , Sandra Gómez  2 , Norma Sberna  3 , Susana Carnovale  4 , Beatriz Caracciolo  4 , Roberto Lede  5
Affiliations
Free article

[Use of posaconazole in children: Experience in a tertiary pediatric hospital]

[Article in Spanish]
María T Rosanova et al. Arch Argent Pediatr. .
Free article

Abstract
in English, Spanish

There is limited information on the use of posaconazole in children. This retrospective and descriptive study was conducted to evaluate the clinical, microbiological characteristics and evolution of patients treated with posaconazole between August 2010 and March 2017. We included 16 children. Median age: 161 months (interquartile range -IQR- 69-173 m). All had underlying disease and a proven invasive fungal infection. The most frequent isolated were Mucor spp. and Aspergillus spp. The mean posaconazole dose was 600 mg/day (400-800 mg/day) and the median duration of treatment was 223 days (IQR 48-632). Ten patients had adverse effects, but only one required suspension of the antifungal treatment due to hydroelectrolytic disorders.

La información sobre el uso de posaconazol en niños es escasa. Se realizó este estudio descriptivo retrospectivo entre agosto de 2010 y marzo de 2017 para evaluar las características clínicas, microbiológicas y la evolución de los pacientes tratados con posaconazol. Se incluyeron 16 niños. Mediana de edad: 161 meses (rango intercuartílico –RIC– 69-173 m). Todos tenían enfermedad subyacente y presentaban infección fúngica invasiva probada. Los aislamientos más frecuentes fueron Mucor spp. y Aspergillus spp. La dosis media de posaconazol fue 600 mg/ día (400-800 mg/día) y la mediana de duración del tratamiento, 223 días (RIC 48-632). Diez pacientes presentaron efectos adversos, pero solo uno requirió suspensión del antifúngico debido a alteraciones hidroelectrolíticas.

Keywords: child; invasive fungal infections; posaconazole; treatment.

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