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Meta-Analysis
. 2018 May 12;10(5):601.
doi: 10.3390/nu10050601.

Maternal Anemia and Low Birth Weight: A Systematic Review and Meta-Analysis

Ana C M G Figueiredo  1 , Isaac S Gomes-Filho  2 , Roberta B Silva  3 , Priscilla P S Pereira  4 , Fabiana A F Da Mata  5 , Amanda O Lyrio  6 , Elivan S Souza  7 , Simone S Cruz  8 , Mauricio G Pereira  9
Affiliations
Meta-Analysis

Maternal Anemia and Low Birth Weight: A Systematic Review and Meta-Analysis

Ana C M G Figueiredo et al. Nutrients. .

Abstract

Objective: To systematically analyze the relationship between maternal anemia and low birth weight.

Methods: A search of studies was conducted in the main databases (Medline, Embase, Scopus, Web of Science, SciELO, and Lilacs), the gray literature, and the reference lists of selected articles. Cohort and case-control studies that met the eligibility criteria were included in the review. There was no limitation on the language or date of publication. Article selection and data extraction were performed by two independent reviewers. Meta-analyses with random effects, subgroup analyses and meta-regressions were performed. Publication bias was measured using Egger regression and visual funnel plot inspection.

Results: A total of 7243 articles were found, of which 71 comprised the systematic review and 68 were included in the meta-analyses. Maternal anemia was associated with low birth weight with an adjusted OR: 1.23 (95% CI: 1.06⁻1.43) and I²: 58%. The meta-regressions confirmed that the sample size and the methodological quality may partially explain the statistical heterogeneity.

Conclusions: Maternal anemia was considered a risk factor for low birth weight.

Keywords: anemia; cohort study; low birth weight; pregnancy; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the search, selection, and inclusion of the studies.
Figure 2
Figure 2
Meta-analysis with crude effect measurement for the evaluated studies and 95% confidence intervals [24,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79].
Figure 3
Figure 3
(a) Publication bias of the crude odds ratio and (b) Publication bias of the adjusted odds ratio.
Figure 4
Figure 4
Meta-analysis with adjusted effect measurements for the evaluated studies and 95% confidence intervals [26,34,36,43,55,59,64,65,68,73,75,80,81].
See this image and copyright information in PMC

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