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. 1988 Sep;8(9):3955-9.
doi: 10.1128/mcb.8.9.3955-3959.1988.

Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5

C Egan  1 , T N Jelsma, J A Howe, S T Bayley, B Ferguson, P E Branton
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Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5

C Egan et al. Mol Cell Biol. 1988 Sep.

Abstract

The binding sites for the 300-, 107-, and 105-kilodalton cellular proteins which associate with human adenovirus type 5 E1A products were studied with E1A deletion mutants. All appeared to bind to the amino-terminal half of E1A products in regions necessary for oncogenic transformation. These results suggest that these cellular species may be important for the biological activity of E1A products.

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References

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