Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May 14;19(5):1462.
doi: 10.3390/ijms19051462.

Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma-A Review

Samadarani B S M Siriwardena  1 , Takaaki Tsunematsu  2 , Guangying Qi  3 , Naozumi Ishimaru  4 , Yasusei Kudo  5
Affiliations
Review

Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma-A Review

Samadarani B S M Siriwardena et al. Int J Mol Sci. .

Abstract

It is well recognized that the presence of cervical lymph node metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial cancer, the first step during the process of metastasis is the invasion of cancer cells into the underlying stroma, breaching the basement membrane (BM)-the natural barrier between epithelium and the underlying extracellular matrix (ECM). The ability to invade and metastasize is a key hallmark of cancer progression, and the most complicated and least understood. These topics continue to be very active fields of cancer research. A number of processes, factors, and signaling pathways are involved in regulating invasion and metastasis. However, appropriate clinical trials for anti-cancer drugs targeting the invasion of OSCC are incomplete. In this review, we summarize the recent progress on invasion-related factors and emerging molecular determinants which can be used as potential for diagnostic and therapeutic targets in OSCC.

Keywords: cell adhesion; cell signaling; epithelial mesenchymal transition (EMT); invasion; metastasis; microRNA; oral squamous cell carcinoma; tumor microenvironment.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Invasion-related molecules in oral squamous cell carcinoma (OSCC). The figure shows invasion-related cell adhesion molecules and invasion-related molecules in a tumor microenvironment (TME), and a cell signaling pathway in OSCC. Red arrows show upregulation in OSCC. Blue arrows show downregulation in OSCC.
See this image and copyright information in PMC

References

    1. Bryne M., Boysen M., Alfsen C.G., Abeler V.M., Sudbø J., Nesland J.M., Kristensen G.B., Piffko J., Bankfalvi A. The invasive front of carcinomas: The most important area for tumor prognosis? Anticancer Res. 1998;18:4757–4764. - PubMed
    1. Dissanayaka W.L., Pitiyage G., Kumarasiri P.V., Liyanage R.L., Dias K.D., Tilakaratne W.M. Clinical and histopathologic parameters in survival of oral squamous cell carcinoma. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 2012;113:518–525. doi: 10.1016/j.oooo.2011.11.001. - DOI - PubMed
    1. Siriwardena B.S.M.S., Tilakaratne A., Amaratunga E.A.P.D., Udagama M.N.G.P.K., Ogawa I., Kudo Y., Takata T., Tilakaratne W.M. Analysis of histopathological and immunohistochemical differences of oral squamous cell carcinoma in young and old patients in Sri Lanka. J. Oral Pathol. Med. 2007;36:357–362. doi: 10.1111/j.1600-0714.2007.00548.x. - DOI - PubMed
    1. Rajapakshe R.M., Pallegama R.W., Jayasooriya P.R., Siriwardena B.S., Attygalla A.M., Hewapathirana S., Weerasinghe J.U., Dias D.K., Tilakaratne W.M. A retrospective analysis to determine factors contributing to the survival of patients with oral squamous cell carcinoma. Cancer Epidemiol. 2015;39:360–366. doi: 10.1016/j.canep.2015.02.011. - DOI - PubMed
    1. Sandu K., Nisa L., Monnier P., Simon C., Andrejevic-Blant S., Bron L. Clinicobiological progression and prognosis of oral squamous cell carcinoma in relation to the tumor invasive front: Impact on prognosis. Acta Otolaryngol. 2014;134:416–424. doi: 10.3109/00016489.2013.849818. - DOI - PubMed

LinkOut - more resources