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Review
. 2018 Jun:126:1-5.
doi: 10.1016/j.critrevonc.2018.03.007. Epub 2018 Mar 29.

Sarcoma-The standard-bearer in cancer discovery

Jared W Potter  1 , Kevin B Jones  1 , Jared J Barrott  2
Affiliations
Review

Sarcoma-The standard-bearer in cancer discovery

Jared W Potter et al. Crit Rev Oncol Hematol. 2018 Jun.

Abstract

Sarcoma is a rare tumor type that occurs most frequently in connective tissue. Despite its uncommon occurrence, sarcoma research has provided the means for groundbreaking research that has advanced our understanding of general cancer mechanisms. It is through sarcoma research that the pioneering efforts of cancer immunotherapy were explored, that we understand the inherent genetic nature of cancer mutations, and that we appreciate the subclassification of general cancer types to make more accurate prognoses. This review explores the brief history of sarcoma research and what sarcomas can still teach us about the future of cancer research, especially in regard to novel immunotherapy targets, the role of epigenetics in disease progression and chemoresistance, and the benefits of more focused clinical trials.

Keywords: Chemoresistance; Epigenetics; Immunotherapy; Mutational burden; Sarcoma.

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Conflict of interest statement

Declaration of interest

None.

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