Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jul;72(1):12-18.
doi: 10.1161/HYPERTENSIONAHA.118.10269. Epub 2018 May 14.

20-HETE: Hypertension and Beyond

Richard J Roman  1 , Fan Fan  2
Affiliations
Review

20-HETE: Hypertension and Beyond

Richard J Roman et al. Hypertension. 2018 Jul.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Initial discoveries implicating 20-HETE in the development of hypertension in the spontaneously hypertensive rat (SHR) and Dahl salt-sensitive (S) rats.
Figure 2
Figure 2
Timeline highlighting milestones leading to the discovery that 20-HETE plays a critical role in the regulation of renal function, vascular tone, hypertension and cardiovascular diseases
Figure 3
Figure 3
Role of 20-HETE in genetic and experimental models of hypertension. The renal and vascular production of 20-HETE is altered in various genetic and experimental models of hypertension and in CYP4A11, CYP4F2 transgenic and Cyp4a transgenic and KO rodents. In general, elevations in the vascular formation of 20-HETE increase renal and peripheral vascular resistance and produce salt-insensitive forms of hypertension, while decreases in renal 20-HETE increase sodium transport and promote salt-sensitive hypertension.
Figure 4
Figure 4
Emerging opportunities for 20-HETE inhibitors and antagonists in the treatment of cardiovascular disease and cancer.
See this image and copyright information in PMC

References

    1. Roman RJ. Alterations in renal medullary hemodynamics and the pressure-natriuretic response in genetic hypertension. Am J Hypertens. 1990;3:893–900. - PubMed
    1. Roman RJ, Kaldunski ML. Enhanced chloride reabsorption in the loop of Henle in Dahl salt-sensitive rats. Hypertension. 1991;17:1018–1024. - PubMed
    1. Schwartzman ML, Abraham NG, Carroll MA, Levere RD, McGiff JC. Regulation of arachidonic acid metabolism by cytochrome P-450 in rabbit kidney. Biochem J. 1986;238:283–290. - PMC - PubMed
    1. Lapuerta L, Chacos N, Falck JR, Jacobson H, Capdevila JH. Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. Am J Med Sci. 1988;295:275–279. - PubMed
    1. Iwai N, Inagami T. Isolation of preferentially expressed genes in the kidneys of hypertensive rats. Hypertension. 1991;17:161–169. - PubMed

Publication types

MeSH terms

Substances