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Review
. 2018 Jul;72(1):12-18.
doi: 10.1161/HYPERTENSIONAHA.118.10269. Epub 2018 May 14.

20-HETE: Hypertension and Beyond

Richard J Roman  1 , Fan Fan  2
Affiliations
Review

20-HETE: Hypertension and Beyond

Richard J Roman et al. Hypertension. 2018 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Initial discoveries implicating 20-HETE in the development of hypertension in the spontaneously hypertensive rat (SHR) and Dahl salt-sensitive (S) rats.
Figure 2
Figure 2
Timeline highlighting milestones leading to the discovery that 20-HETE plays a critical role in the regulation of renal function, vascular tone, hypertension and cardiovascular diseases
Figure 3
Figure 3
Role of 20-HETE in genetic and experimental models of hypertension. The renal and vascular production of 20-HETE is altered in various genetic and experimental models of hypertension and in CYP4A11, CYP4F2 transgenic and Cyp4a transgenic and KO rodents. In general, elevations in the vascular formation of 20-HETE increase renal and peripheral vascular resistance and produce salt-insensitive forms of hypertension, while decreases in renal 20-HETE increase sodium transport and promote salt-sensitive hypertension.
Figure 4
Figure 4
Emerging opportunities for 20-HETE inhibitors and antagonists in the treatment of cardiovascular disease and cancer.
See this image and copyright information in PMC

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