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. 2018 Apr;35(2):222-224.
doi: 10.5114/ada.2018.75249. Epub 2018 Apr 24.

A desensitization protocol for delayed allergy to cytarabine: analysis of two cases

Marcello Albanesi  1 , Paola Carluccio  2 , Andrea Nico  1 , Lucia Giliberti  1 , Danilo Di Bona  1 , Maria Filomena Caiaffa  3 , Giorgina Specchia  2 , Luigi Macchia  1
Affiliations

A desensitization protocol for delayed allergy to cytarabine: analysis of two cases

Marcello Albanesi et al. Postepy Dermatol Alergol. 2018 Apr.
No abstract available

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Figures

Figure 1
Figure 1
A, B – Representative pictures of cutaneous lesions for case 1 and case 2. Similar lesions were scattered on the whole body. As for case 1, the lesion shown does not correspond to the site of injection of cytarabine. C – Case 2. Lymphocyte proliferation assessed after 5 days of culture with the indicated concentrations of cytarabine or phytohemagglutinin M (PHA-M). The ratio between the different cytarabine concentrations and negative control is shown above each Histogramm column. Error bars correspond to SEM. D – A dose-time desensitization curve of cytarabine
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References

    1. Castleberry RP, Crist WM, Holbrook T, et al. The cytosine arabinoside (Ara-C) syndrome. Med Pediatr Oncol. 1981;9:257–64. - PubMed
    1. Shepherd GM. Hypersensitivity reactions to chemotherapeutic drugs. Clin Rev Allergy Immunol. 2003;24:253–62. - PubMed
    1. Cacoub P, Musette P, Descamps V, et al. The DRESS syndrome: a literature review. Am J Med. 2011;124:588–97.. - PubMed
    1. Rassiga AL, Schwartz HJ, Forman WB, Crum ED. Cytarabine-induced anaphylaxis. Demonstration of antibody and successful desensitization. Arch Intern Med. 1980;140:425–6. - PubMed
    1. Ozkan A, Apak H, Celkan T, et al. Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside. Pediatr Dermatol. 2001;18:38–40. - PubMed

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