Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Apr 30:5:97.
doi: 10.3389/fmed.2018.00097. eCollection 2018.

Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

Dahlene N Fusco  1   2 , Lilia Ganova-Raeva  3 , Yury Khudyakov  3 , Lili Punkova  3 , Aisha Mohamed  4 , Scarlett Se Yun Cheon  5 , Prapti Koirala  5 , Karin L Andersson  6 , Gonzague Jourdain  7   8   9 , Camille Sureau  10 , Raymond T Chung  6 , Georg Lauer  6
Affiliations
Case Reports

Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

Dahlene N Fusco et al. Front Med (Lausanne). .

Abstract

A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy.

Keywords: HBV vaccine escape mutant; HCV; hepatitis B virus; preS2 deletion; surface antibody escape mutant.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Chronological results for hepatitis B virus (HBV) and hepatitis C virus (HCV) studies. Y-axis indicates HBV (left) and HCV (right) viral load over time (X-axis). HCV RNA is indicated in yellow, HBV DNA in blue. HBV surface antibody (Anti-HBs), surface antigen (HBsAg), E antibody (anti-HBe), E antigen (HBeAg), and core antibody (anti-HBc) results are presented corresponding to the day of collection.
Figure 2
Figure 2
Schematic of the mutant genome. The in-frame deletion is not affecting the ORFS, but shortens pre-S2 and Pol by the corresponding two amino acids. A total of 1,380 truncates the polymerase to 82 amino acids.
See this image and copyright information in PMC

References

    1. Bersoff-Matcha SJ, Cao K, Jason M, Ajao A, Jones SC, Meyer T, et al. Hepatitis B virus reactivation associated with direct-acting antiviral therapy for chronic hepatitis C virus: a review of cases reported to the U.S. Food and Drug Administration adverse event reporting system. Ann Intern Med (2017) 166(11):792–8. 10.7326/M17-0377 - DOI - PubMed
    1. Sa-Nguanmoo P, Tangkijvanich P, Thawornsuk N, Vichaiwattana P, Prianantathavorn K, Theamboonlers A, et al. Molecular epidemiological study of hepatitis B virus among migrant workers from Cambodia, Laos, and Myanmar to Thailand. J Med Virol (2010) 82(8):1341–9. 10.1002/jmv.21828 - DOI - PubMed
    1. Zanetti AR, Tanzi E, Manzillo G, Maio G, Sbreglia C, Caporaso N, et al. Hepatitis B variant in Europe. Lancet (1988) 2(8620):1132–3. - PubMed
    1. Tong S, Revill P. Overview of hepatitis B viral replication and genetic variability. J Hepatol (2016) 64(1 Suppl):S4–16. 10.1016/j.jhep.2016.01.027 - DOI - PMC - PubMed
    1. Sticchi L, Caligiuri P, Cacciani R, Alicino C, Bruzzone B. Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: implications for surveillance and detection of new escape variants. Hum Vaccin Immunother (2013) 9(3):568–71. - PMC - PubMed

Publication types

LinkOut - more resources