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. 2018 May 15;5(5):CD011283.
doi: 10.1002/14651858.CD011283.pub2.

Processed electroencephalogram and evoked potential techniques for amelioration of postoperative delirium and cognitive dysfunction following non-cardiac and non-neurosurgical procedures in adults

Yodying Punjasawadwong  1 , Waraporn Chau-In, Malinee Laopaiboon, Sirivimol Punjasawadwong, Pathomporn Pin-On
Affiliations

Processed electroencephalogram and evoked potential techniques for amelioration of postoperative delirium and cognitive dysfunction following non-cardiac and non-neurosurgical procedures in adults

Yodying Punjasawadwong et al. Cochrane Database Syst Rev. .

Abstract

Background: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) may complicate a patient's postoperative recovery in several ways. Monitoring of processed electroencephalogram (EEG) or evoked potential (EP) indices may prevent or minimize POD and POCD, probably through optimization of anaesthetic doses.

Objectives: To assess whether the use of processed EEG or auditory evoked potential (AEP) indices (bispectral index (BIS), narcotrend index, cerebral state index, state entropy and response entropy, patient state index, index of consciousness, A-line autoregressive index, and auditory evoked potentials (AEP index)) as guides to anaesthetic delivery can reduce the risk of POD and POCD in non-cardiac surgical or non-neurosurgical adult patients undergoing general anaesthesia compared with standard practice where only clinical signs are used.

Search methods: We searched CENTRAL, MEDLINE, Embase and clinical trial registry databases up to 28 March 2017. We updated this search in February 2018, but these results have not been incorporated in the review.

Selection criteria: We included randomized or quasi-randomized controlled trials comparing any method of processed EEG or evoked potential techniques (entropy, BIS, AEP etc.) against a control group where clinical signs were used to guide doses of anaesthetics in adults aged 18 years or over undergoing general anaesthesia for non-cardiac or non-neurosurgical elective operations.

Data collection and analysis: We used the standard methodological procedures expected by Cochrane. Our primary outcomes were: occurrence of POD; and occurrence of POCD. Secondary outcomes included: all-cause mortality; any postoperative complications; and postoperative length of stay. We used GRADE to assess the quality of evidence for each outcome.

Main results: We included six randomized controlled trials (RCTs) with 2929 participants comparing processed EEG or EP indices-guided anaesthesia with clinical signs-guided anaesthesia. There are five ongoing studies and one study awaiting classification.Anaesthesia administration guided by the indices from a processed EEG (bispectral index) probably reduces the risk of POD within seven days after surgery with risk ratio (RR) of 0.71 (95% CI 0.59 to 0.85; number needed to treat for an additional beneficial outcome (NNTB) of 17, 95% CI 11 to 34; 2197 participants; 3 RCTs; moderate quality of evidence). Three trials also showed the lower rate of POCD at 12 weeks after surgery (RR 0.71, 95% CI 0.53 to 0.96; NNTB 38, 95% CI 21 to 289; 2051 participants; moderate-quality evidence), but it is uncertain whether processed EEG indices reduce POCD at one week (RR 0.84, 95% CI 0.69 to 1.02; 3 trials; 1989 participants; moderate-quality evidence), and at 52 weeks (RR 0.30, 95% CI 0.05 to 1.80; 1 trial; 59 participants; very low quality of evidence). There may be little or no effect on all-cause mortality (RR 1.01, 95% CI 0.62 to 1.64; 1 trial; 1155 participants; low-quality evidence). One trial suggested a lower risk of any postoperative complications with processed EEG (RR 0.51, 95% CI 0.37 to 0.71; 902 participants, moderate-quality evidence). There may be little or no effect on reduced postoperative length of stay (mean difference -0.2 days, 95% CI -2.02 to 1.62; 1155 participants; low-quality evidence).

Authors' conclusions: There is moderate-quality evidence that optimized anaesthesia guided by processed EEG indices could reduce the risk of postoperative delirium in patients aged 60 years or over undergoing non-cardiac surgical and non-neurosurgical procedures. We found moderate-quality evidence that postoperative cognitive dysfunction at three months could be reduced in these patients. The effect on POCD at one week and over one year after surgery is uncertain. There are no data available for patients under 60 years. Further blinded randomized controlled trials are needed to elucidate strategies for the amelioration of postoperative delirium and postoperative cognitive dysfunction, and their consequences such as dementia (including Alzheimer's disease (AD)) in both non-elderly (below 60 years) and elderly (60 years or over) adult patients. The one study awaiting classification and five ongoing studies may alter the conclusions of the review once assessed.

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Conflict of interest statement

Yodying Punjasawadwong was involved in an included study (Punjasawadwong 2016) as a primary investigator. Dr Punjasawadwong did not assess the risk of bias and perform data extraction in this trial.

Waraporn Chau‐in: none known

Malinee Laopaiboon: none known

Sirivimol Punjasawadwong: none known

Pathomporn Pin‐on: none known

Figures

1
1
Study flow diagram.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
4
4
Forest plot of comparison: 1 Processed EEG versus clinical signs guided anaesthesia, outcome: 1.1 POD.
5
5
Forest plot of comparison: 1 Processed EEG versus clinical signs guided anaesthesia, outcome: 1.2 POCD at one week.
6
6
Forest plot of comparison: 1 Processed EEG versus clinical signs guided anaesthesia, outcome: 1.3 POCD at 12 weeks.
1.1
1.1. Analysis
Comparison 1 Processed EEG versus clinical signs guided anaesthesia (available data analysis), Outcome 1 POD.
1.2
1.2. Analysis
Comparison 1 Processed EEG versus clinical signs guided anaesthesia (available data analysis), Outcome 2 POCD at one week.
1.3
1.3. Analysis
Comparison 1 Processed EEG versus clinical signs guided anaesthesia (available data analysis), Outcome 3 POCD at 12 weeks.
2.1
2.1. Analysis
Comparison 2 Processed EEG versus clinical signs guided anaesthesia (sensitivity analysis), Outcome 1 POD.
2.2
2.2. Analysis
Comparison 2 Processed EEG versus clinical signs guided anaesthesia (sensitivity analysis), Outcome 2 POCD at one week.
2.3
2.3. Analysis
Comparison 2 Processed EEG versus clinical signs guided anaesthesia (sensitivity analysis), Outcome 3 POCD at 12 weeks.
See this image and copyright information in PMC

Update of

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