Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May 15;113(5):489-491.
doi: 10.1111/vox.12661. Online ahead of print.

Accuracy of a history of blood donation from surrogate witnesses: data from the UK TMER study

J M Mackenzie  1 , M Turner  2 , K Morris  3 , S Field  4 , A M Molesworth  1 , S Pal  1 , R G Will  1 , C A Llewelyn  5 , P E Hewitt  6
Affiliations

Accuracy of a history of blood donation from surrogate witnesses: data from the UK TMER study

J M Mackenzie et al. Vox Sang. .

Abstract

Look-back studies of blood transfusion in Creutzfeldt-Jakob disease commonly rely on reported history from surrogate witnesses. Data from the UK Transfusion Medicine Epidemiology Review have been analysed to determine the accuracy of the blood donation history provided by the relatives of cases. Our results show that only a small percentage of cases were found to be registered as donors on UK Blood Service (UKBS) databases when there was no family report of blood donation. In contrast, a history of reported donation was less accurate.

Keywords: donors; epidemiology; prions.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) Variant CJD (vCJD). (b) Sporadic CJD (sCJD). *The data for blood donation pre‐1990 are incomplete.
See this image and copyright information in PMC

References

    1. Urwin PJ, Mackenzie JM, Llewelyn CA, et al: Creutzfeldt‐Jakob disease and blood transfusion: updated results of the UK Transfusion Medicine Epidemiology Review Study. Vox Sang 2016; 110:310–316 - PubMed
    1. Dorsey K, Zou S, Schonberger LB, et al: Lack of evidence of transfusion transmission of Creutzfeldt‐Jakob disease in a US surveillance study. Transfusion 2009; 49:977–984 - PubMed
    1. Puopolo M, Ladogana A, Vetrugno V, et al: Transmission of sporadic Creutzfeldt‐Jakob disease by blood transfusion: risk factor or possible biases. Transfusion 2011; 51:1556–1566 - PubMed

LinkOut - more resources