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Book

Angiotensin II

Preeti Patel, Devang K. Sanghavi  1 , Deborah L. Morris  2 , Chadi I. Kahwaji  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Angiotensin II

Preeti Patel et al.
Free Books & Documents

Excerpt

Angiotensin is a peptide endocrine hormone and an important part of the renin-angiotensin-aldosterone system, an inter-related endocrine system important in volume and blood pressure control. Angiotensinogen, an alpha-globulin, and the peptide prohormone is synthesized primarily by the liver and circulates in plasma. Angiotensin II (AT-II) has recently received FDA approval for use in patients in shock. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of AT-II therapy in the clinical setting as relates to the essential points needed by members of an interprofessional team managing the care of patients presenting with shock.

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Conflict of interest statement

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Devang Sanghavi declares no relevant financial relationships with ineligible companies.

Disclosure: Deborah Morris declares no relevant financial relationships with ineligible companies.

Disclosure: Chadi Kahwaji declares no relevant financial relationships with ineligible companies.

References

    1. Angiotensin II (Giapreza) for septic shock. Med Lett Drugs Ther. 2018 Dec 03;60(1561):199-200. - PubMed
    1. Romero CA, Carretero OA. A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback. Curr Hypertens Rep. 2019 Jan 18;21(1):8. - PMC - PubMed
    1. Sacha GL, Bauer SR, Lat I. Vasoactive Agent Use in Septic Shock: Beyond First-Line Recommendations. Pharmacotherapy. 2019 Mar;39(3):369-381. - PubMed
    1. Rodriguez R, Cucci M, Kane S, Fernandez E, Benken S. Novel Vasopressors in the Treatment of Vasodilatory Shock: A Systematic Review of Angiotensin II, Selepressin, and Terlipressin. J Intensive Care Med. 2020 Apr;35(4):327-337. - PubMed
    1. Buckley MS, Barletta JF, Smithburger PL, Radosevich JJ, Kane-Gill SL. Catecholamine Vasopressor Support Sparing Strategies in Vasodilatory Shock. Pharmacotherapy. 2019 Mar;39(3):382-398. - PubMed

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