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Book

Succinylcholine Chloride

Heather H. Hager  1 , Preeti Patel, Bracken Burns  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Succinylcholine Chloride

Heather H. Hager et al.
Free Books & Documents

Excerpt

Succinylcholine is a short-acting depolarizing neuromuscular blocking agent approved by the FDA for co-administration with sedatives or hypnotics. By blocking acetylcholine, succinylcholine disrupts cholinergic receptors in the parasympathetic and sympathetic nervous systems, leading to skeletal muscle relaxation. This mechanism facilitates rapid endotracheal intubation, surgical procedures, and mechanical ventilation. Off-label use includes adjunctive therapy during electroconvulsive therapy to control electrically induced muscle contractions.

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Conflict of interest statement

Disclosure: Heather Hager declares no relevant financial relationships with ineligible companies.

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Bracken Burns declares no relevant financial relationships with ineligible companies.

References

    1. Cook D, Simons DJ. StatPearls [Internet] StatPearls Publishing; Treasure Island (FL): 2023. Nov 13, Neuromuscular Blockade. - PubMed
    1. Blauvelt G, Burdick K, Cannon EJ. Nursing Considerations When Using Neuromuscular Blocking Agents to Assist With Intubation: A Review of Literature. Crit Care Nurs Q. 2019 Jan/Mar;42(1):30-40. - PubMed
    1. Ahmad M, Khan NA, Furqan A. Comparing The Functional Outcome Of Different Dose Regimes Of Succinylcholine When Used For Rapid Induction And Intubation. J Ayub Med Coll Abbottabad. 2018 Jul-Sep;30(3):401-404. - PubMed
    1. Acquisto NM, Mosier JM, Bittner EA, Patanwala AE, Hirsch KG, Hargwood P, Oropello JM, Bodkin RP, Groth CM, Kaucher KA, Slampak-Cindric AA, Manno EM, Mayer SA, Peterson LN, Fulmer J, Galton C, Bleck TP, Chase K, Heffner AC, Gunnerson KJ, Boling B, Murray MJ. Society of Critical Care Medicine Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient: Executive Summary. Crit Care Med. 2023 Oct 01;51(10):1407-1410. - PubMed
    1. Yang HS, Joung KW. Electroconvulsive therapy and muscle relaxants. Anesth Pain Med (Seoul) 2023 Oct;18(4):447-448. - PMC - PubMed

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