Infliximab
- PMID: 29763197
- Bookshelf ID: NBK500021
Infliximab
Excerpt
This activity discusses the mechanism of action and clinical applications of infliximab, a monoclonal antibody targeting tumor necrosis factor-alpha (TNF-α). This FDA-approved therapy addresses inflammatory conditions, including Crohn disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and severe plaque psoriasis. The program details infliximab's pharmacokinetics, dosing considerations, contraindications, and monitoring protocols, offering healthcare professionals a comprehensive understanding essential for personalized patient care. Highlighting the significance of an interprofessional approach, this initiative emphasizes the collaborative effort necessary to navigate infliximab therapy effectively. This educational endeavor aims to optimize treatment strategies, mitigate adverse events, and enhance clinical outcomes across diverse patient populations by empowering healthcare professionals with evidence-based insights.
Copyright © 2025, StatPearls Publishing LLC.
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- Liu Y, Liu S, Liu L, Gong X, Liu J, Sun L, Liu X, Wu L, Chen L, Wang L, Luo L, Lin J, Tie N, Jiang Z, Wu J, Lu F, Sun H, Li X, Yang N, Chai K, Wei H, Da Z, Zhao C, Dai L, Wang Y, Shi G, Zhang Z, Song H, Guo Q, Liu YC, Li Z. Fine Comparison of the Efficacy and Safety Between GB242 and Infliximab in Patients with Rheumatoid Arthritis: A Phase III Study. Rheumatol Ther. 2022 Feb;9(1):175-189. - PMC - PubMed
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- Maini R, St Clair EW, Breedveld F, Furst D, Kalden J, Weisman M, Smolen J, Emery P, Harriman G, Feldmann M, Lipsky P. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group. Lancet. 1999 Dec 04;354(9194):1932-9. - PubMed
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