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Comment
. 2018 May 14;33(5):793-795.
doi: 10.1016/j.ccell.2018.04.007.

Targeting the (Un)differentiated State of Cancer

Lajos V Kemeny  1 , David E Fisher  2
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Targeting the (Un)differentiated State of Cancer

Lajos V Kemeny et al. Cancer Cell. .
Free article

Abstract

Dedifferentation in cancer is associated with intrinsic and acquired resistance to therapies. In this issue of Cancer Cell, Tsoi et al. identify four differentiation states in melanoma and provide evidence that melanoma cells develop drug resistance through a stepwise dedifferentiation process, making them vulnerable to ferroptotic cell death-inducing compounds.

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