Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Nov;33(22):3326-3329.
doi: 10.1080/14786419.2018.1474466. Epub 2018 May 15.

Pinellia ternata (Thunb.) Makino Preparation promotes sleep by increasing REM sleep

Sisi Lin  1 , Bo Nie  2 , Guihong Yao  3 , Hui Yang  4 , Ren Ye  1 , Zhengzhong Yuan  1
Affiliations

Pinellia ternata (Thunb.) Makino Preparation promotes sleep by increasing REM sleep

Sisi Lin et al. Nat Prod Res. 2019 Nov.

Abstract

Pinellia ternata (Thunb.) Makino Preparation (PTP) is widely used to treat insomnia in traditional Chinese medicine; however, its specific role is not clear. In this study, PTP was prepared at three concentrations. For locomotor activity tests, mice were treated with PTP and evaluated for 14 days. For polygraph recordings, mice were treated for 14 days and recorded after treatment. The main chemical constituents in PTP were identified by Ultra performance liquid chromatography/quadrupole time spectrometry (UPLC/Q-TOF-MS). The results showed that 0.9 g/mL PTP significantly reduced locomotor activity. The effect was related to the time of treatment. PTP reduced wakefulness and increased sleep in mice. Furthermore, PTP promoted sleep by increasing the number of REM sleep episodes with a duration of 64-128s and increasing the number of transitions from NREM sleep to REM sleep and from REM sleep to wakefulness. A total of 17 compounds were identified.

Keywords: Pinellia ternata (Thunb.) Makino Preparation; mice; promote sleep.

PubMed Disclaimer

Substances

LinkOut - more resources