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Comparative Study
. 2018 May 15;18(1):563.
doi: 10.1186/s12885-018-4485-4.

Clinicopathological features, surgical strategy and prognosis of duodenal gastrointestinal stromal tumors: a series of 300 patients

Zhen Liu  1   2 , Gaozan Zheng  1 , Jinqiang Liu  1   3 , Shushang Liu  1 , Guanghui Xu  1 , Qiao Wang  1   4 , Man Guo  1 , Xiao Lian  1 , Hongwei Zhang  5 , Fan Feng  6
Affiliations
Comparative Study

Clinicopathological features, surgical strategy and prognosis of duodenal gastrointestinal stromal tumors: a series of 300 patients

Zhen Liu et al. BMC Cancer. .

Abstract

Background: The relatively low incidence of duodenal gastrointestinal stromal tumors (GISTs) and the unique anatomy make the surgical management and outcomes of this kind of tumor still under debate. Thus, this study aimed to explore the optimal surgical strategy and prognosis of duodenal GISTs.

Methods: A total of 300 cases of duodenal GISTs were obtained from our center (37 cases) and from case reports or series (263 cases) extracted from MEDLINE. Clinicopathological features, type of resections and survivals of duodenal GISTs were analyzed.

Results: The most common location of duodenal GISTs was descending portion (137/266, 51.5%). The median tumor size was 4 cm (0.1-28). Most patients (66.3%) received limited resection (LR). Pancreaticoduodenectomy (PD) was mainly performed for GISTs with larger tumor size or arose from descending portion (both P < 0.05). For both the entire cohort and tumors located in the descending portion, PD was not an independent risk factor for disease-free survival (DFS) and disease-specific survival (DSS) (both P > 0.05). Duodenal GISTs were significantly different from gastric GISTs with respect to tumor size, mitotic index and NIH risk category (all P < 0.05). The DFS and DSS of duodenal GISTs was significantly worse than that of gastric GISTs (both P < 0.05).

Conclusions: LR was a more prevalent surgical procedure and PD was mainly performed for tumors with larger diameter or located in descending portion. Type of resection was not an independent risk factor for the prognosis of duodenal GISTs. Prognosis of duodenal GISTs was significantly worse than that of gastric GISTs.

Keywords: Duodenum; Features; Gastrointestinal stromal tumor; Prognosis; Surgery.

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Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Ethics Committee of Xijing Hospital, and written informed consent was obtained from the patients in our center.

Competing interests

There are no financial or other relations that could lead to a conflict of interest.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
DFS and DSS of duodenal GISTs
Fig. 2
Fig. 2
DFS and DSS of duodenal GISTs stratified by surgical procedure
Fig. 3
Fig. 3
DFS and DSS of descending duodenal GISTs stratified by surgical procedure
Fig. 4
Fig. 4
Comparison of DFS and DSS between duodenal and gastric GISTs
See this image and copyright information in PMC

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