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. 2018 May 20;21(5):408-412.
doi: 10.3779/j.issn.1009-3419.2018.05.09.

[Analysis of the First Diagnosis Symptom and Its Influencing Factors in 500 Patients with Lung Cancer]

[Article in Chinese]
Xin Zhang  1 , Puyuan Xing  1 , Xuezhi Hao  1 , Junling Li  1
Affiliations

[Analysis of the First Diagnosis Symptom and Its Influencing Factors in 500 Patients with Lung Cancer]

[Article in Chinese]
Xin Zhang et al. Zhongguo Fei Ai Za Zhi. .

Abstract
in English, Chinese

Background: As the morbidity and mortality in lung cancer keep raising, we are here to discuss the effect of clinical features especially the initial symptomon on diagnosis and follow-up treatment of newly diagnosed lung cancer patients.

Methods: The clinical features of the 500 patients with lung cancer in our hospital from March, 2017 to May, 2017 were analyzed retrospectively, including the initial symptom, stage, biomarkers, pathology, etc. RESULTS: There were 266 famle (53.3%), 372 adenocarcinoma (74.4%), 285 smokers (58%), status score of most patients (98.2%) was 0-1. 58.2% (n=291) of all the patients got biomarkers test, of which epidermal growth factor receptor (EGFR) mutations was 61.2%(178/291), anaplasticlymphoma kinase (ALK) fusion gene positive was 4.1% (12/291). Smoking status, initial symptom, pathological typing, TNM staging and EGFR mutation were the main factors affecting follow-up treatment.

Conclusions: Patients with typical symptoms have shorter diagnosis time. Smoking status, lung cancer-related symptoms, pathology, TNM staging and EGFR mutation status are the main factors that affect the follow-up treatment.

【中文题目：500例肺癌患者首诊症状及其影响因素分析】 【中文摘要：背景与目的 肺癌的发病率与死亡率不断升高，本研究探讨初诊肺癌患者临床特征，特别是首诊症状对诊断及后续治疗选择的影响。方法 回顾性分析自2017年3月-2017年5月我院胸内科门诊就诊的500例肺癌患者，分析其临床特征包括首发症状、分期、生物标志物、病理等对后续治疗选择影响。结果 女性（53.3%）、腺癌（74.4%）、吸烟者（58%）多见，大部分患者（98.2%）体力状态评分为0分-1分。生物标志物检测58.2%（n=291），其中表皮生长因子受体（epidermal growth factor receptor, EGFR）突变61.2%（178/291），间变性淋巴瘤激酶（anaplasticlymphoma kinase, ALK）融合基因阳性4.1%（12/291）。不同吸烟状况、是否有症状、病理分型、疾病分期和是否有突变是影响后续治疗的主要因素。结论 就诊时有典型症状的患者确诊时间更短，吸烟状况、肺癌相关症状、病理、疾病分期及突变状况是影响后续治疗的主要因素。 】 【中文关键词：肺肿瘤；症状；诊断；治疗；影响因素】.

Keywords: Diagnosis; Influencing factors; Lung neoplasms; Symptom; Treatment.

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References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30. doi: 10.3322/caac.21387. - DOI - PubMed
    1. Kris MG, Benowitz SI, Adams S, et al. Clinical cancer advances 2010: annual report on progress against cancer from the American Society of Clinical Oncology. J Clin Oncol. 2010;28(36):5327–5347. doi: 10.1200/JCO.2010.33.2742. - DOI - PubMed
    1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–132. doi: 10.3322/caac.21338. - DOI - PubMed
    1. Shibuya K, Inoue M, Lopez AD. Statistical modeling and projections of lung cancer mortality in 4 industrialized countries. Int J Cancer. 2005;117(3):476–485. doi: 10.1002/ijc.21078. - DOI - PubMed
    1. Edwards BK, Brown ML, Wingo PA, et al. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst. 2005;97(19):1407–1427. doi: 10.1093/jnci/dji289. - DOI - PubMed

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