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. 2018 May 1:11:151.
doi: 10.3389/fnmol.2018.00151. eCollection 2018.

ADNP, a Microtubule Interacting Protein, Provides Neuroprotection Through End Binding Proteins and Tau: An Amplifier Effect

Illana Gozes  1 , Yanina Ivashko-Pachima  1 , Carmen L Sayas  2
Affiliations

ADNP, a Microtubule Interacting Protein, Provides Neuroprotection Through End Binding Proteins and Tau: An Amplifier Effect

Illana Gozes et al. Front Mol Neurosci. .
No abstract available

Keywords: ADNP; microtubule end binding proteins; microtubule-associated proteins; microtubules; tau.

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Figures

Figure 1
Figure 1
The illustration shows the mechanism of NAP/ADNP neuroprotection against tauopathy in the disease state. In the healthy state, ADNP enhances axonal transport and synaptic plasticity. ADNP has two adjacent SIP motifs, one within the NAP sequence and one upstream (Bassan et al., ; Zamostiano et al., 2001). A NAP—related peptide SKIP (encompassing the SxIP motif), enhances axonal transport in Adnp haploinsufficient mice, probably through the same mechanism (Amram et al., 2016). In tissue culture cells, NAP also enhances dendritic spine formation (synaptic plasticity) through an EB3-depedent mechanism (Oz et al., 2014).
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