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. 2018 May 1:12:168.
doi: 10.3389/fnhum.2018.00168. eCollection 2018.

Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults

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Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults

Elmira Ismaylova et al. Front Hum Neurosci. .

Abstract

Numerous studies have shown differences in the functioning in the areas of the frontal-limbic circuitry between depressed patients and controls. However, current knowledge on frontal-limbic neural substrates of individual differences in mood states in everyday life in healthy individuals is scarce. The present study investigates anatomical, resting-state, and functional neural correlates of daily mood states in healthy individuals. We expected to observe associations between mood and the frontal-limbic circuitry and the default-mode network (DMN). A total of 42 healthy adults (19 men, 23 women; 34 ± 1.2 years) regularly followed for behavior and psychosocial functioning since age of 6, underwent a functional magnetic resonance imaging scan, and completed a daily diary of mood states and related cognitions for 5 consecutive days. Results showed that individuals with smaller left hippocampal gray matter volumes experienced more negative mood and rumination in their daily life. Greater resting-state functional connectivity (rsFC) within the DMN, namely between posterior cingulate cortex (PCC) and medial prefrontal cortex regions as well as between PCC and precuneus, was associated with both greater negative and positive mood states in daily life. These rsFC results could be indicative of the role of the DMN regional functioning in emotional arousal, irrespective of valence. Lastly, greater daily positive mood was associated with greater activation in response to negative emotional stimuli in the precentral gyri, previously linked to emotional interference on cognitive control. Altogether, present findings might reflect neural mechanisms underlying daily affect and cognition among healthy individuals.

Keywords: daily mood; default-mode network; emotion; fMRI; left hippocampus.

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Figures

FIGURE 1
FIGURE 1
T-Statistic maps of the negative association between regional left hippocampal gray matter volume and daily negative mood and rumination. Both images were taken at peak Montreal Neurological Institute coordinates: –24, –18, –9 and presented at the whole-brain level of voxel p < 0.001. There was no significant association after FWE correction.
FIGURE 2
FIGURE 2
Positive correlation between daily negative mood and resting-state connectivity between posterior cingulate cortex (PCC) and medial prefrontal cortex (MPFC), frontal poles, anterior cingulate cortex (ACC), as well as between PCC and precuneus. PCC-based seed-to-voxel connectivity 3D map presented using CONN toolbox. (A) Left red cluster depicts MPFC, frontal poles, and ACC positively coupled with PCC. Right red cluster depicts precuneus positively coupled with PCC. (B) Scatter-plot for visual inspection illustrates the result from the extracted mean connectivity values of the left cluster within the default-mode network (DMN). Data was taken at peak Montreal Neurological Institute (MNI) coordinates: –4, 40, –6; k = 609; cluster pFWE< 0.001. (C) Scatter-plot for visual inspection illustrates the result from the extracted mean connectivity values of the right cluster within the DMN. Data was taken at MNI coordinates: –6, –54, 34; k = 939; cluster pFWE< 0.001.
FIGURE 3
FIGURE 3
Positive correlation between daily positive mood and resting-state connectivity between posterior cingulate cortex (PCC) and frontal poles and anterior cingulate cortex (ACC), as well as between PCC and precuneus. PCC-based seed-to-voxel connectivity 3D map presented using CONN toolbox. (A) Right red cluster depicts frontal poles and ACC positively coupled with PCC. Left red cluster depicts precuneus positively coupled with PCC. (B) Scatter-plot for visual inspection illustrates the result from the extracted mean connectivity values of the right cluster within the default-mode network (DMN). Data was taken at peak Montreal Neurological Institute (MNI) coordinates: 2, 56, 12; k = 437; cluster pFWE< 0.001. (C) Scatter-plot for visual inspection illustrates the result from the extracted mean connectivity values of the left cluster within the DMN. Data was taken at MNI coordinates: –10, –50, 38; k = 1980; cluster pFWE< 0.001.

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