Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2018 Dec;20(12):1522-1528.
doi: 10.1007/s12094-018-1881-9. Epub 2018 May 15.

Consensus document on the progression and treatment response criteria in gastroenteropancreatic neuroendocrine tumors

X Merino-Casabiel  1 , J Aller  2 , J Arbizu  3 , R García-Figueiras  4 , C González  5 , E Grande  6 , P Jiménez-Fonseca  7 , M I Sevilla  8 , J Capdevila  9
Affiliations
Practice Guideline

Consensus document on the progression and treatment response criteria in gastroenteropancreatic neuroendocrine tumors

X Merino-Casabiel et al. Clin Transl Oncol. 2018 Dec.

Abstract

Purpose: Gastroenteropancreatic neuroendocrine tumors are a heterogeneous group of low incidence neoplasms characterized by a low proliferative activity and slow growth. Their response to targeted therapies is heterogeneous and often does not lead to tumor shrinkage. Thus, evaluation of the therapeutic response should differ from other kind of tumors.

Methods: To answer relevant questions about which techniques are best in the assessment of progression or treatment response a RAND/UCLA-based consensus process was implemented. Relevant clinical questions were listed followed by a systematic search of the literature. The expert panel answered all questions with recommendations, combining available evidence and expert opinion. Recommendations were validated through a questionnaire and a participatory meeting.

Results: Expert recommendations regarding imaging tools for tumor assessment and evaluation of progression were agreed upon. Available imaging techniques were reviewed and recommendations for best patient monitoring practice and the best way to evaluate treatment response were formulated.

Keywords: Diagnostic imaging; Molecular imaging; Neuroendocrine tumors; Nuclear medicine; Radionuclide imaging.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

Javier Aller has received speaker honorarium and as an advisory board and consensus member from Novartis. Enrique Grande has received speaker honorarium from Novartis. Isabel Sevilla has received speaker honorarium and as advisory board member from Novartis. Jaume Capdevila has received funding for a research grant and as advisory board member from Novartis. The rest of the authors declare that they have no conflict of interest.

Ethical approval

The study has been performed in accordance with the ethical standards of the Declaration of Helsinki and its later amendments. This article does not contain any data derived from studies with human participants or animals performed by any of the authors.

Informed consent

As this work is based on studies previously published, informed consent was not needed.

References

    1. Lawrence B, Gustafsson BI, Chan A, Svejda B, Kidd M, Modlin IM. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin N Am. 2011;40(1):1–18 (vii). doi: 10.1016/j.ecl.2010.12.005. - DOI - PubMed
    1. de Mestier L, Dromain C, d’Assignies G, Scoazec JY, Lassau N, Lebtahi R, et al. Evaluating digestive neuroendocrine tumor progression and therapeutic responses in the era of targeted therapies: state of the art. Endocr Relat Cancer. 2014;21(3):R105–R120. doi: 10.1530/ERC-13-0365. - DOI - PubMed
    1. Kim KW, Krajewski KM, Nishino M, Jagannathan JP, Shinagare AB, Tirumani SH, et al. Update on the management of gastroenteropancreatic neuroendocrine tumors with emphasis on the role of imaging. AJR Am J Roentgenol. 2013;201(4):811–824. doi: 10.2214/AJR.12.10240. - DOI - PMC - PubMed
    1. Held-Warmkessel J, Schiech L. Responding to four gastrointestinal complications in cancer patients. Nursing. 2008;38(7):32–38. doi: 10.1097/01.nurse.0000325340.92199.e9. - DOI - PubMed
    1. Vinik AI, Woltering EA, Warner RRP, Caplin M, O’Dorisio TM, Wiseman GA, et al. NANETS consensus guidelines for the diagnosis of neuroendocrine tumor. Pancreas. 2010;39(6):713–734. doi: 10.1097/mpa.0b013e3181ebaffd. - DOI - PubMed

Publication types

MeSH terms

Supplementary concepts

LinkOut - more resources