Metastatic Breast Cancer Collateral Damage Project (MBCCD): Scale development and preliminary results of the Survey of Health, Impact, Needs, and Experiences (SHINE)

Timothy J Williamson¹, Susan M Love², Jessica N Clague DeHart³, Alexandra Jorge-Miller^{1

4}, Leah Eshraghi², Heather Cooper Ortner², Annette L Stanton^{5

6

7

8}

Affiliations

¹ Department of Psychology, University of California, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA.
² Dr. Susan Love Research Foundation, Encino, CA, USA.
³ Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
⁴ Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
⁵ Department of Psychology, University of California, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA. astanton@ucla.edu.
⁶ Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. astanton@ucla.edu.
⁷ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA. astanton@ucla.edu.
⁸ Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA, USA. astanton@ucla.edu.

PMID: 29767345
PMCID: PMC6239969
DOI: 10.1007/s10549-018-4823-x

Metastatic Breast Cancer Collateral Damage Project (MBCCD): Scale development and preliminary results of the Survey of Health, Impact, Needs, and Experiences (SHINE)

Timothy J Williamson et al. Breast Cancer Res Treat. 2018 Aug.

. 2018 Aug;171(1):75-84.

doi: 10.1007/s10549-018-4823-x. Epub 2018 May 16.

Authors

Timothy J Williamson¹, Susan M Love², Jessica N Clague DeHart³, Alexandra Jorge-Miller^{1

4}, Leah Eshraghi², Heather Cooper Ortner², Annette L Stanton^{5

6

7

8}

Affiliations

¹ Department of Psychology, University of California, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA.
² Dr. Susan Love Research Foundation, Encino, CA, USA.
³ Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
⁴ Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
⁵ Department of Psychology, University of California, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095-1563, USA. astanton@ucla.edu.
⁶ Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA. astanton@ucla.edu.
⁷ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA. astanton@ucla.edu.
⁸ Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA, USA. astanton@ucla.edu.

PMID: 29767345
PMCID: PMC6239969
DOI: 10.1007/s10549-018-4823-x

Abstract

Purpose: Until recently, people with metastatic breast cancer (MBC) had a very poor prognosis. New treatment approaches have prolonged the time that people with MBC live, but their quality of life has received less attention. Consequently, the needs and concerns across financial, vocational, psychological, social, and physical domains in MBC patients are poorly understood-particularly regarding the collateral damage or longer-term, life-altering impacts of MBC and its treatments. This study's aims were to characterize MBC-related collateral damage, identify groups most likely to experience collateral damage, and examine its associations with psychological health, illness management, and health behaviors.

Methods: Participants (N = 515) with MBC were recruited from Dr. Susan Love Research Foundation's Army of Women® and other advocacy organizations. Participants completed questionnaires of MBC-related collateral damage, depressive symptoms, anxiety, self-efficacy for managing oncologic treatments and physical symptoms, sleep, and physical activity.

Results: Eight domains of MBC-related collateral damage, as well as MBC-related benefit finding, were reliably characterized. Concerns about mortality/uncertainty were most prominent. Participants also endorsed high levels of benefit finding. Participants younger than 50 years, with limited financial resources, or with children under 18 at home reported the most collateral damage. Collateral damage was associated significantly with compromised psychological health, lower illness management efficacy, and poorer health behaviors, beyond sociodemographic and medical characteristics.

Conclusions: Subgroups of MBC patients report long-term, life-altering consequences of MBC and its treatments, which relate to important health outcomes. Clinical implications and recommendations are discussed.

Keywords: Collateral damage; Metastatic breast cancer; Psycho-oncology; Quality of life; Supportive care; Survivorship.

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Conflict of interest statement

Conflict of interest The authors declare that they have no conflicts of interest.

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References

1. Siegel RL, Miller KD, Jemal A. Cancer statistics (2018) CA Cancer J Clin 68(1):7–30 - PubMed
1. Mariotto AB, Etzioni R, Hurlbert M, Penberthy L, Mayer M (2017) Estimation of the number of women living with metastatic breast cancer in the United States. Cancer Epidemiol Biomarkers Prev 26(6):809–815 - PMC - PubMed
1. Swain SM, Baselga J, Kim S- B, Ro J, Semiglazov V, Campone M et al. (2015) Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med 372(8):724–734 - PMC - PubMed
1. Reed E, Simmonds P, Haviland J, Corner J (2012) Quality of life and experience of care in women with metastatic breast cancer: a cross-sectional survey. J Pain Symptom Manage 43(4):747–758 - PubMed
1. Slovacek L, Slovackova B, Slanska I, Petera J, Priester P (2010) Quality of life and depression among metastatic breast cancer patients. Med Oncol 27(3):958–959 - PubMed

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Metastatic Breast Cancer Collateral Damage Project (MBCCD): Scale development and preliminary results of the Survey of Health, Impact, Needs, and Experiences (SHINE)

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Metastatic Breast Cancer Collateral Damage Project (MBCCD): Scale development and preliminary results of the Survey of Health, Impact, Needs, and Experiences (SHINE)

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