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Comment
. 2018 May 15;48(5):842-843.
doi: 10.1016/j.immuni.2018.04.034.

TREMendous 2 Be Social

Narghes Calcagno  1 , Caroline Baufeld  1 , Charlotte Madore  1 , Oleg Butovsky  2
Affiliations
Comment

TREMendous 2 Be Social

Narghes Calcagno et al. Immunity. .

Abstract

TREM2 is known for its role in microglial phagocytosis and in neurodegenerative diseases. In this issue of Immunity, Filipello et al. (2018) show that microglial TREM2 is required for synaptic pruning in early development. TREM2-deficient mice show altered social behavior in adulthood, linking TREM2 to neurodevelopmental disease.

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Figures

Figure 1.
Figure 1.. TREM2 Is Required for Synaptic Refinement, Brain Connectivity, and Social Behavior
TREM2 is expressed by microglia in the CNS. During development, microglia engulf excessive spines and neurons in order to shape normal brain connectivity. The lack of TREM2 is shown here to impair synapse elimination, which is accompanied by a reduction of functional brain connectivity. In adult mice, this leads to alterations in social behavior. These findings demonstrate a novel role of TREM2 in neurodevelopment.
See this image and copyright information in PMC

Comment on

References

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