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Comment
. 2018 May 15;48(5):849-851.
doi: 10.1016/j.immuni.2018.04.033.

Trained Microglia Trigger Memory Loss

Iva Lelios  1 , Melanie Greter  2
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Free article
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Trained Microglia Trigger Memory Loss

Iva Lelios et al. Immunity. .
Free article

Abstract

Innate immune training is a recently described mechanism that allows innate cells to recollect a previous inflammatory episode. In a recent issue of Nature, Wendeln et al. (2018) show that peripheral inflammation can alter long-term microglia function, influencing neuropathology later in life.

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  • Innate immune memory in the brain shapes neurological disease hallmarks.
    Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze JL, Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ. Wendeln AC, et al. Nature. 2018 Apr;556(7701):332-338. doi: 10.1038/s41586-018-0023-4. Epub 2018 Apr 11. Nature. 2018. PMID: 29643512 Free PMC article.

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