Peek-Peak-Pique: Repeating Motifs of Subtle Variance Are Targets for Potent Malaria Antibodies
- PMID: 29768173
- DOI: 10.1016/j.immuni.2018.04.037
Peek-Peak-Pique: Repeating Motifs of Subtle Variance Are Targets for Potent Malaria Antibodies
Abstract
Biomedical interventions to curb malaria-causing Plasmodium falciparum (Pf) infections are critically needed. Two studies in Nature Medicine,Kisalu et al. (2018) and Tan et al. (2018), report the isolation of potent human antibodies that target a new epitope on Pf sporozoites and mediate effective parasite inhibition in pre-clinical models.
Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
Comment on
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A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19. Nat Med. 2018. PMID: 29554083 Free PMC article.
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A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.Nat Med. 2018 May;24(4):401-407. doi: 10.1038/nm.4513. Epub 2018 Mar 19. Nat Med. 2018. PMID: 29554084 Free PMC article.
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