Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Aug;137(1):15-23.
doi: 10.1007/s10633-018-9640-3. Epub 2018 May 16.

Deferoxamine-induced electronegative ERG responses

Ruben Jauregui  1   2   3 , Karen Sophia Park  1   2 , Alexander G Bassuk  4 , Vinit B Mahajan  5   6 , Stephen H Tsang  7   8   9   10
Affiliations
Case Reports

Deferoxamine-induced electronegative ERG responses

Ruben Jauregui et al. Doc Ophthalmol. 2018 Aug.

Abstract

Purpose: To report a case of deferoxamine-induced retinopathy characterized by electroretinography (ERG), optical coherence tomography angiography (OCT-A), and other multimodal imaging.

Methods: This is an observational case report of one patient. Full-field ERG was performed. OCT-A, spectral-domain optical coherence tomography (SD-OCT), color fundus photography, and fundus autofluorescence were used to characterize the retinopathy induced by deferoxamine use.

Results: A 64-year-old man with a history of β-thalassemia intermedia presented with worsening visual acuity, nyctalopia, and electronegative ERG. OCT-A revealed atrophy of the choriocapillaris in areas of hypoautofluorescence, corresponding to regions of retinal atrophy. SD-OCT showed disruption of the ellipsoid zone, granular hyperreflective deposits within the retinal pigment epithelium, thinning of the retinal layers, and extensive choroidal sclerosis and atrophy of the retinal pigment epithelium.

Conclusion: Deferoxamine-induced retinopathy can manifest with electronegative maximal ERG responses, and OCT-A can be used to detect deferoxamine toxicity.

Keywords: Deferoxamine; Electronegative; Multimodal imaging; OCT-A; Retinopathy.

PubMed Disclaimer

References

    1. Prog Retin Eye Res. 2015 Mar;45:58-110 - PubMed
    1. Surv Ophthalmol. 2008 Jan-Feb;53(1):16-40 - PubMed
    1. Doc Ophthalmol. 2008 Jan;116(1):57-60 - PubMed
    1. PLoS One. 2017 May 10;12(5):e0177059 - PubMed
    1. Ophthalmology. 2012 Aug;119(8):1693-700 - PubMed

Publication types

MeSH terms

LinkOut - more resources