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Review
. 2018 May 17;14(5):e1006971.
doi: 10.1371/journal.ppat.1006971. eCollection 2018 May.

Lessons from bacteriophages part 1: Deriving utility from protein structure, function, and evolution

Kunica Asija  1 , Carolyn M Teschke  1
Affiliations
Review

Lessons from bacteriophages part 1: Deriving utility from protein structure, function, and evolution

Kunica Asija et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
(A) Capsid structure of bacteriophage P22. The left side of panel A shows the mature P22 capsid. The pentons are highlighted in blue, and hexons are shown in gray. The asymmetric unit (seven subunits) of the capsid is represented in ribbon format in the center of the capsid. The asymmetric unit is magnified and shown on the right of the panel. (B) Ribbon diagrams of coat monomers of P22 (left) and HK97 (right). The A-domains, P-domains, E-loops, and N-arms have been highlighted in cyan, green, yellow, and red, respectively. The I-domain of P22 coat protein has been highlighted in coral. The arrows indicate the D-loop (purple) of the monomer of P22 (left) and the G-loop (purple) on the monomer of HK97 (right).
Fig 2
Fig 2. Phage use in vaccine design and delivery.
The left panel shows the use of a VLP to express an antigenic gene product on its capsid. The right panel shows an antigenic gene being cloned into the phage genome and its subsequent use as a DNA vaccine carrier. VLP, virus-like particle.
See this image and copyright information in PMC

References

    1. Keen EC. A century of phage research: bacteriophages and the shaping of modern biology. Bioessays. 2015;37(1):6–9. doi: 10.1002/bies.201400152 . - DOI - PMC - PubMed
    1. Crick FH, Barnett L, Brenner S, Watts-Tobin RJ. General nature of the genetic code for proteins. Nature. 1961;192:1227–32. . - PubMed
    1. Brenner S, Jacob F, Meselson M. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature. 1961;190:576–81. . - PubMed
    1. Taylor K, Hradecna Z, Szybalski W. Asymmetric distribution of the transcribing regions on the complementary strands of coliphage lambda DNA. Proc Natl Acad Sci U S A. 1967;57(6):1618–25. . - PMC - PubMed
    1. Georgopoulos C. Toothpicks, serendipity and the emergence of the Escherichia coli DnaK (Hsp70) and GroEL (Hsp60) chaperone machines. Genetics. 2006;174(4):1699–707. doi: 10.1534/genetics.104.68262 . - DOI - PMC - PubMed

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