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Comment
. 2018 May 16;98(4):671-672.
doi: 10.1016/j.neuron.2018.05.006.

Common Grounds for Family Maladies

Konrad Oexle  1 , Juliane Winkelmann  2
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Free article
Comment

Common Grounds for Family Maladies

Konrad Oexle et al. Neuron. .
Free article

Abstract

Rare variants cause Mendelian family aggregation in subsets of common diseases, and common variants may contribute to rare diseases. In this issue of Neuron, Gormley et al. (2018) report that the common variant burden in familial migraine is larger than in migraine of the general population.

Keywords: Brugada syndrome; HEY2; common disease; common variants; family aggregation; migraine; rare disorders; rare variants.

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  • Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
    Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M; 23andMe Research Team; International Headache Genetics Consortium (IHGC); Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A. Gormley P, et al. Neuron. 2018 May 16;98(4):743-753.e4. doi: 10.1016/j.neuron.2018.04.014. Epub 2018 May 3. Neuron. 2018. PMID: 29731251 Free PMC article.

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