Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 May 16;98(4):673-675.
doi: 10.1016/j.neuron.2018.05.002.

Ataxin-2 Is Droppin' Some Knowledge

Lindsay A Becker  1 , Aaron D Gitler  2
Affiliations
Free article
Comment

Ataxin-2 Is Droppin' Some Knowledge

Lindsay A Becker et al. Neuron. .
Free article

Abstract

Ataxin-2 is an RNA-binding protein involved in translation regulation and mutated in neurodegenerative diseases, including ALS. In this issue of Neuron, Bakthavachalu et al. (2018) demonstrate that higher-order ataxin-2 RNA/protein assemblies are necessary for both translation-dependent learning and ALS-associated neurodegeneration in Drosophila.

Keywords: ALS; Ataxin-2; RNP granules; liquid-liquid phase separation; translational control.

PubMed Disclaimer

Comment on

LinkOut - more resources