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Review
. 2018 May 16;7(5):43.
doi: 10.3390/cells7050043.

Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Emily J Rutherford  1 , Arnold D K Hill  2 , Ann M Hopkins  3
Affiliations
Review

Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Emily J Rutherford et al. Cells. .

Abstract

Although the developments in cellular and molecular biology over the last few decades have significantly advanced our understanding of the processes and players that regulate invasive disease, many areas of uncertainty remain. This review will discuss the contribution of dysregulated cell⁻cell and cell⁻matrix adhesion to the invasion in both benign and malignant contexts. Using the endometrium as an illustrative tissue that undergoes clinically significant invasion in both contexts, the adhesion considerations in the cells ("seed") and their microenvironment ("soil") will be discussed. We hope to orientate this discussion towards translational relevance for the diagnosis and treatment of endometrial conditions, which are currently associated with significant morbidity and mortality.

Keywords: ICAM-1; VCAM-1; adhesion; biomarkers; endometrial cancer; endometriosis; endometrium; inflammation; integrins; microenvironment; seed and soil.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Integrin expression in benign and malignant contexts.
Figure 2
Figure 2
Adhesion molecules in the immune system context.
See this image and copyright information in PMC

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