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Review
. 2018 May 17;23(5):1204.
doi: 10.3390/molecules23051204.

Characterization of Cyclodextrin/Volatile Inclusion Complexes: A Review

Miriana Kfoury  1 , David Landy  2 , Sophie Fourmentin  3
Affiliations
Review

Characterization of Cyclodextrin/Volatile Inclusion Complexes: A Review

Miriana Kfoury et al. Molecules. .

Abstract

Cyclodextrins (CDs) are a family of cyclic oligosaccharides that constitute one of the most widely used molecular hosts in supramolecular chemistry. Encapsulation in the hydrophobic cavity of CDs positively affects the physical and chemical characteristics of the guests upon the formation of inclusion complexes. Such a property is interestingly employed to retain volatile guests and reduce their volatility. Within this scope, the starting crucial point for a suitable and careful characterization of an inclusion complex is to assess the value of the formation constant (Kf), also called stability or binding constant. This task requires the application of the appropriate analytical method and technique. Thus, the aim of the present paper is to give a general overview of the main analytical tools used for the determination of Kf values for CD/volatile inclusion complexes. This review emphasizes on the advantages, inconvenients and limits of each applied method. A special attention is also dedicated to the improvement of the current methods and to the development of new techniques. Further, the applicability of each technique is illustrated by a summary of data obtained from the literature.

Keywords: HPLC; ITC; NMR; SH-GC; TOC; UV-Visible; cyclodextrin; fluorescence; formation constant; phase solubility; volatiles.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic illustration of the formation of an inclusion complex between a cyclodextrin (host) and a guest.
Figure 2
Figure 2
Schematic representation of the main stoichiometries of the inclusion complexes.
Figure 3
Figure 3
Schematic representation of the spectral displacement method.
Figure 4
Figure 4
Phase solubility profiles and classification of inclusion complexes according to Higuchi and Connors [115].
See this image and copyright information in PMC

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