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Review
. 2018;18(10):834-843.
doi: 10.2174/1568026618666180518101028.

The Development of New Small-Molecule Inhibitors Targeting Bacterial Metallo-β-lactamases

Ping Wang  1   2 , Jing Cheng  1   2 , Cong-Cong Liu  1   2 , Kai Tang  1   2 , Feng Xu  1   2 , Zhiqiang Yu  3 , Bin Yu  1   2   3   4 , Junbiao Chang  1   4
Affiliations
Review

The Development of New Small-Molecule Inhibitors Targeting Bacterial Metallo-β-lactamases

Ping Wang et al. Curr Top Med Chem. 2018.

Abstract

Metallo-β-lactamases (MBLs) are a family of Zn(II)-dependent enzymes that can hydrolyze almost all β-lactam antibiotics. Horizontal transfer of the genes encoding MBLs among Gram-negative bacteria pathogens has led to the emergence of extensively drug-resistant pathogens, which now represent a major threat to human health. As there is not to date yet a clinically available MBL inhibitor, the discovery of new MBL inhibitors has great urgency. This review highlights the recent developments in the discovery of small-molecule MBL inhibitors.

Keywords: Metallo-β-lactamases; cyclic Boronates; dicarboxylic acid derivatives; natural products; peptide inhibitors; thiol derivatives; triazoles..

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