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Comment
. 2018 May 17;14(5):e8335.
doi: 10.15252/msb.20188335.

Learning lessons in sepsis from the children

Steven Timmermans  1   2 , Claude Libert  1   2
Affiliations
Comment

Learning lessons in sepsis from the children

Steven Timmermans et al. Mol Syst Biol. .

Abstract

Sepsis research has had relatively limited therapeutic success so far. In their recent study, Kobzik and colleagues (Joachim et al, 2018) identify novel drug‐sensitive pathways in sepsis, derived exclusively from patient data. Their strategy is based on the analysis of a naturally sepsis‐resistant population (pre‐puberty children) and on the implementation of a novel‐rich Pathway Drug Network, constructed from human gene expression data enriched in drug–pathway–gene clusters.

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Figures

Figure 1
Figure 1. Resistance to sepsis in children links to candidate drugs via a rich Pathway Drug Network
The workflow used in the study by Joachim et al (2018) involves two key aspects. First, the authors constructed the PDN, based on the Comparative Toxicogenomics Database (CTD), the Pharmacogenomics Knowledgebase (PharmGKB), the Connectivity Map (CMap), and Pathprint. Second, they used this PDN to compare differential pathways between children and adults undergoing sepsis, to identify candidate drugs, which were then validated in a mouse model.
See this image and copyright information in PMC

Comment on

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