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Editorial
. 2018 Jun 7;13(6):825-828.
doi: 10.2215/CJN.05090418. Epub 2018 May 17.

Ptolemy and Copernicus Revisited: The Complex Interplay between the Kidneys and Heart Failure

Steven G Coca  1
Affiliations
Editorial

Ptolemy and Copernicus Revisited: The Complex Interplay between the Kidneys and Heart Failure

Steven G Coca. Clin J Am Soc Nephrol. .
No abstract available

Keywords: Acute Kidney Injury; Atherosclerosis; Atherosclerotic Events; heart failure; kidney.

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Figures

Figure 1.
Figure 1.
Opposing views of the role of the kidneys in relation to dysfunction of other organs in the body. In the Ptolemaic viewpoint, the kidneys are seen as a key “driver” of dysfunction of other organs, including the heart, lungs, vasculature, etc. In this viewpoint, AKI can directly contribute to heart failure. In contrast, the Copernican viewpoint holds these key organs in the center and the kidneys as an orbiting planet. In this paradigm, dysfunction of heart, lungs, vasculature, liver, etc. result in kidney injury and/or reductions in glomerular filtration rate. Exogenous factors, such as nephrotoxins, can also injury the kidney. In the Copernican viewpoint, AKI and heart failure often co-exist as they “travel in the similar/parallel orbits,” yet the true origin of heart failure and AKI was due to initial insults from the centric organs.
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References

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