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. 2018 Aug;32(8):1401-1405.
doi: 10.1038/s41433-018-0100-9. Epub 2018 May 18.

Evaluation of vascular changes with optical coherence tomography angiography after ruthenium-106 brachytherapy of circumscribed choroidal hemangioma

Gilda Cennamo  1 , Claudia Rossi  2 , Maria Angelica Breve  2 , Nunzio Velotti  3 , Antonio Farella  4 , Raffaele Liuzzi  5 , Giovanni Cennamo  2
Affiliations

Evaluation of vascular changes with optical coherence tomography angiography after ruthenium-106 brachytherapy of circumscribed choroidal hemangioma

Gilda Cennamo et al. Eye (Lond). 2018 Aug.

Abstract

Purpose: To describe the vascular changes of circumscribed choroidal hemangioma (CCH) after ruthenium-106 brachytherapy using optical coherence tomography angiography (angio-OCT).

Methods: Seven eyes of 7 patients diagnosed with symptomatic CCH who underwent ruthenium-106 plaque radiotherapy were included in the study. Patients underwent complete ophthalmic examination, bulbar echography and angio-OCT. The same protocol was applied 1 year after ruthenium-106 brachytherapy.

Results: At baseline, the mean best-corrected visual acuity (BCVA) in affected eyes was 0.67 ± 0.14 logMAR, and the mean tumor thickness was 4.46 ± 0.91 mm measured by standardized A-scan echography. After ruthenium-106 plaque treatment, the mean BCVA increased to 0.17 ± 0.10 logMAR (p = 0.001) and the mean tumor thickness to 2.29 ± 0.71 mm (p = 0.003). Moreover, there was a significant reduction of the tumor basal diameter (p= 0.009). Intra-tumor angio-OCT measurements revealed a statistically significant reduction of the vessel and flow areas (p = 0.006 and p = 0.002, respectively) 1 year after brachytherapy.

Conclusions: Angio-OCT is a non-invasive reliable method with which to evaluate the vascular features of CCH and consequently to monitor changes after conservative treatment.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Circumscribed choroidal hemangioma before and 1 year after treatment with ruthenium plaque radiotherapy. a Multicolor image of a choroidal circumscribed hemangioma. b EDI-OCT scan through the tumor before treatment shows low-to-medium homogeneous reflective signals from the lesions and elevation of retinal pigment epithelium with intra-subretinal fluid and cystoid macular edema. c EDI-OCT scan through the tumor after treatment shows resolution of intra-subretinal fluid and of cystoid macular edema. d Angio-OCT revealed a network of variably sized interconnected vessels in the hemangioma, which appeared larger than the surrounding normal choroidal vessels. e Angio-OCT image showing reduced vessel area after treatment
See this image and copyright information in PMC

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