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Review
. 2018 Jun;17(6):435-453.
doi: 10.1038/nrd.2018.71. Epub 2018 May 18.

RNA-modifying proteins as anticancer drug targets

P Ann Boriack-Sjodin  1 , Scott Ribich  1 , Robert A Copeland  1
Affiliations
Review

RNA-modifying proteins as anticancer drug targets

P Ann Boriack-Sjodin et al. Nat Rev Drug Discov. 2018 Jun.

Abstract

All major biological macromolecules (DNA, RNA, proteins and lipids) undergo enzyme-catalysed covalent modifications that impact their structure, function and stability. A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA stability and translation to proteins; these mechanisms of translational control have been termed epitranscriptomics. Emerging data suggest that some epitranscriptomic mechanisms are altered in human cancers as well as other human diseases. In this Review, we examine the current understanding of RNA modifications with a focus on mRNA methylation, highlight their possible roles in specific cancer indications and discuss the emerging potential of RNA-modifying proteins as therapeutic targets.

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