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. 1986 Mar;1(1):83-90.
doi: 10.1007/BF00998479.

Phosphofructokinase activity in fibroblasts from patients with Alzheimer's disease and age- and sex-matched controls

N R Sims  1 , J P Blass
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Phosphofructokinase activity in fibroblasts from patients with Alzheimer's disease and age- and sex-matched controls

N R Sims et al. Metab Brain Dis. 1986 Mar.

Abstract

The activity of the enzyme phosphofructokinase (PFK) was comparable in cultured skin fibroblasts from eight patients with Alzheimer's disease and eight age- and sex-matched controls. Mean activities were similar in the two groups whether measured under nonallosteric conditions at pH 8.0 or under allosteric conditions at pH 7.0, in the presence of 0.1 or 1 mM ATP. Activities of PFK in Alzheimer's disease and control cells also showed a similar temperature dependence and similar isozyme patterns on column chromatography. These results argue against the existence of significant structural variations of PFK in Alzheimer's disease.

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