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. 1988 Dec;32(12):1901-3.
doi: 10.1128/AAC.32.12.1901.

Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity

C S Taft  1 , T Stark, C P Selitrennikoff
Affiliations

Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity

C S Taft et al. Antimicrob Agents Chemother. 1988 Dec.

Abstract

Cilofungin (LY121019) inhibited Candida albicans growth and activity of (1-3)-beta-glucan synthase, for which it was a noncompetitive inhibitor with a Ki-app of 2.5 microM. Cilofungin had no effect on chitin synthase activity. Based on these and other data, it seems likely that cilofungin inhibits fungal growth by inhibiting (1-3)-beta-glucan synthase activity.

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