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Comment
. 2018 May 17;173(5):1066-1068.
doi: 10.1016/j.cell.2018.05.005.

Neurons Are the Inflammatory Problem

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Neurons Are the Inflammatory Problem

Kevin J Tracey. Cell. .
Free article

Abstract

The discovery that reflex neuronal circuits control immunity provided a new mechanistic understanding of infection and injury. Pinho-Ribeiro et al. (2018) report that lethal tissue destruction from streptococcal necrotizing fasciitis ("flesh-eating disease") occurs because sensory neurons reflexively inhibit frontline immune responses.

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