Neurons Are the Inflammatory Problem
- PMID: 29775588
- DOI: 10.1016/j.cell.2018.05.005
Neurons Are the Inflammatory Problem
Abstract
The discovery that reflex neuronal circuits control immunity provided a new mechanistic understanding of infection and injury. Pinho-Ribeiro et al. (2018) report that lethal tissue destruction from streptococcal necrotizing fasciitis ("flesh-eating disease") occurs because sensory neurons reflexively inhibit frontline immune responses.
Copyright © 2018. Published by Elsevier Inc.
Comment on
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Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection.Cell. 2018 May 17;173(5):1083-1097.e22. doi: 10.1016/j.cell.2018.04.006. Epub 2018 May 10. Cell. 2018. PMID: 29754819 Free PMC article.
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