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Review
. 2018 Jul:170:120-126.
doi: 10.1016/j.clineuro.2018.05.015.

The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review

M Monticelli  1 , P Zeppa  2 , F Zenga  2 , R Altieri  2 , M Mammi  2 , L Bertero  3 , I Castellano  3 , P Cassoni  3 , A Melcarne  2 , G La Rocca  4 , G Sabatino  4 , A Ducati  2 , D Garbossa  2
Affiliations
Free article
Review

The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review

M Monticelli et al. Clin Neurol Neurosurg. 2018 Jul.
Free article

Abstract

Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior. The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.

Keywords: BRAF; Glioblastoma; High grade gliomas; IDH1; IDH2; MGMT; Molecular biology; TERT.

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