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Review
. 2018 Jun;32(2):253-268.
doi: 10.1016/j.idc.2018.02.002.

Long-Term Liver Disease, Treatment, and Mortality Outcomes Among 17,000 Persons Diagnosed with Chronic Hepatitis C Virus Infection: Current Chronic Hepatitis Cohort Study Status and Review of Findings

Anne C Moorman  1 , Loralee B Rupp  2 , Stuart C Gordon  2 , Yuna Zhong  3 , Jian Xing  3 , Mei Lu  4 , Joseph A Boscarino  5 , Mark A Schmidt  6 , Yihe G Daida  7 , Eyasu H Teshale  3 , Philip R Spradling  3 , Scott D Holmberg  3 ; CHeCS Investigators
Affiliations
Review

Long-Term Liver Disease, Treatment, and Mortality Outcomes Among 17,000 Persons Diagnosed with Chronic Hepatitis C Virus Infection: Current Chronic Hepatitis Cohort Study Status and Review of Findings

Anne C Moorman et al. Infect Dis Clin North Am. 2018 Jun.

Abstract

Chronic Hepatitis Cohort Study (CHeCS) publications using data from "real-world" patients with hepatitis C virus (HCV) have described demographic disparities in access to care; rates of advanced liver disease, morbidity, and mortality (2.5%-3.5% per year during 2006-10, although only 19% of all CHeCS decedents, and just 30% of those with deaths attributed to liver disease, had HCV listed on death certificate); substantial comorbidities, such as diabetes, advanced liver fibrosis (29% prevalence), renal disease, and depression, and partial reversal of all these with successful antiviral therapy; patient risk behaviors; and use of noninvasive markers to assess liver disease.

Keywords: Cirrhosis; Comorbidities; Direct-acting antiviral; Hepatitis C; Mortality; Real-world cohort; Sustained viral response.

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Conflict of interest statement

Conflict of Interest: The authors have made the following disclosures: S.C. Gordon receives grant/research support from AbbVie Pharmaceuticals (M15–410, M13–576, M15–942, M14–222, M13–590, M14–227, M14–868), Conatus (IDN-6556–14, IDN-6556–120), CymaBay (CB8025–21629, CB8025–31731), Gilead Pharmaceuticals (GS-US-330–1508, GS-US-320–4018, GS-US-367–1170, GS-US-367–1171, GS-US-367–1172, GS-US-367–1173, GS-US-334–0154, GS-US-337–4063, IN-US-337–3957), Intercept Pharmaceuticals (747–303, 747–301, 747–302, 747–207, [Master agreement dated Nov 9, 2015, with Statements of Work 1–3 for Fibrotic Liver Diseases (FOLD) study]), and Merck (MK5172–017, MK5172–062, MK3682–035, MK3682–041, MK3682–012, MK3682–021). He is also a consultant/advisor for Abbvie, Gilead, Intercept, and Merck. L.B. Rupp, M. Lu, J.A. Boscarino, M.A. Schmidt, and Y.G. Daida receive research grant support from Gilead Pharmaceuticals (IN-US-337–3957) and Intercept (Master agreement dated Nov 9, 2015, with Statements of Work 1–3 for Fibrotic Liver Diseases (FOLD) study).

References

    1. Moorman AC, Gordon SC, Rupp LR, et al. Baseline characteristics and mortality among people in care for chronic viral hepatitis: the Chronic Hepatitis Cohort Study (CHeCS). Clin Infect Dis 2013;56:40–50. - PubMed
    1. Lu M, Rupp LB, Moorman AC, et al. Comparative effectiveness research of Chronic Hepatitis B and C Cohort Study (CHeCS): improving data collection and cohort identification. Dig Dis Sci 2014;59:3053–61. - PMC - PubMed
    1. Abara WE, Moorman AC, Zhou Y, et al. The predictive value of International Classification of Disease Codes for chronic hepatitis C virus infection surveillance: the utility and limitations of electronic health records. Popul Health Manag. [Epub ahead of print]. - PMC - PubMed
    1. Mahajan R, Moorman A, Liu S, et al. Use of the International Classification of Diseases, 9th revision, coding in identifying chronic hepatitis B virus infection in health system data: implications for national surveillance. J Am Med Inform Assoc 2013;20:441–5. - PMC - PubMed
    1. Boscarino JA, Lu M, Moorman AC, et al. Predictors of poor mental and physical health status among patients with chronic hepatitis C infection: the Chronic Hepatitis Cohort Study (CHeCS). Hepatology 2015;61:802–11. - PMC - PubMed

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